Histological topographical comparisons of atherosclerosis progression in juveniles and young adults
Abstract Background The histologically topographic comparisons on atherosclerosis progression among three anatomical sites, mid-thoracic and lower abdominal aorta and left anterior descending coronary artery (LAD) were performed using a young population (age 15–34 years) from the Pathobiological Det...
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| Veröffentlicht in: | Atherosclerosis 2008-04, Vol.197 (2), p.791-798 |
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| creator | Homma, Satoki Troxclair, Dana A Zieske, Arthur W Malcom, Gray T Strong, Jack P |
| description | Abstract Background The histologically topographic comparisons on atherosclerosis progression among three anatomical sites, mid-thoracic and lower abdominal aorta and left anterior descending coronary artery (LAD) were performed using a young population (age 15–34 years) from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Methods and results The histological classification based on the American Heart Association grading scheme showed that in the thoracic aorta type 2 lesions (numerous macrophage foam cells with fine particles but no pools of extracellular lipid) appeared in the first 10-year age group, with no significant change in prevalence in the next 10 years. Lesions greater than type 2 were rarely seen in the thoracic aorta. Although type 2 lesions appeared later in the LAD than in the aorta, the lesions within the LAD progressed rapidly to more advanced lesions (types 4 and 5) or atheroma. Lesion development in the abdominal aorta was intermediate to lesion development in the thoracic aorta and the LAD. Conclusions The most striking topographic difference on lesion progression among the three anatomical sites was the vulnerability of type 2 lesions to progress into advanced lesions. The histology study, including immunohistochemistry limited to the type 2 lesions suggested that lesion progression was related to the intimal thickness and the amount of collagen but not to the number of macrophage foam cells. |
| doi_str_mv | 10.1016/j.atherosclerosis.2007.07.027 |
| format | Article |
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Methods and results The histological classification based on the American Heart Association grading scheme showed that in the thoracic aorta type 2 lesions (numerous macrophage foam cells with fine particles but no pools of extracellular lipid) appeared in the first 10-year age group, with no significant change in prevalence in the next 10 years. Lesions greater than type 2 were rarely seen in the thoracic aorta. Although type 2 lesions appeared later in the LAD than in the aorta, the lesions within the LAD progressed rapidly to more advanced lesions (types 4 and 5) or atheroma. Lesion development in the abdominal aorta was intermediate to lesion development in the thoracic aorta and the LAD. Conclusions The most striking topographic difference on lesion progression among the three anatomical sites was the vulnerability of type 2 lesions to progress into advanced lesions. The histology study, including immunohistochemistry limited to the type 2 lesions suggested that lesion progression was related to the intimal thickness and the amount of collagen but not to the number of macrophage foam cells.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2007.07.027</identifier><identifier>PMID: 17869259</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adolescence ; Adolescent ; Adult ; African Americans ; AHA classification ; Aorta ; Aorta, Abdominal - pathology ; Aorta, Thoracic - pathology ; Arteriosclerosis ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - classification ; Atherosclerosis - pathology ; Autopsy ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular ; Collagen ; Coronary arteries ; Coronary Artery Disease - pathology ; European Continental Ancestry Group ; Fatty streaks ; Female ; Histology ; Histometry ; Humans ; Immunohistochemistry ; Intimal thickness ; Macrophage ; Male ; Medical sciences ; Neurology ; PDAY ; Prevalence ; Sex Factors ; Smooth muscle cells ; T-lymphocytes ; Topography ; Tunica Intima - pathology ; Tunica Media - pathology ; United States - epidemiology ; Vascular diseases and vascular malformations of the nervous system ; Young people</subject><ispartof>Atherosclerosis, 2008-04, Vol.197 (2), p.791-798</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2007 Elsevier Ireland Ltd</rights><rights>2008 INIST-CNRS</rights><rights>2007 Elsevier Ireland Ltd. All rights reserved. 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4977-95ce6e6bc829c26475e224bc5b5f2e097c8ab1270e2293a7b5a9439c66fbdb5f3</citedby><cites>FETCH-LOGICAL-c4977-95ce6e6bc829c26475e224bc5b5f2e097c8ab1270e2293a7b5a9439c66fbdb5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.atherosclerosis.2007.07.027$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20273945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17869259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Homma, Satoki</creatorcontrib><creatorcontrib>Troxclair, Dana A</creatorcontrib><creatorcontrib>Zieske, Arthur W</creatorcontrib><creatorcontrib>Malcom, Gray T</creatorcontrib><creatorcontrib>Strong, Jack P</creatorcontrib><creatorcontrib>for the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group</creatorcontrib><creatorcontrib>Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group</creatorcontrib><title>Histological topographical comparisons of atherosclerosis progression in juveniles and young adults</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Background The histologically topographic comparisons on atherosclerosis progression among three anatomical sites, mid-thoracic and lower abdominal aorta and left anterior descending coronary artery (LAD) were performed using a young population (age 15–34 years) from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Methods and results The histological classification based on the American Heart Association grading scheme showed that in the thoracic aorta type 2 lesions (numerous macrophage foam cells with fine particles but no pools of extracellular lipid) appeared in the first 10-year age group, with no significant change in prevalence in the next 10 years. Lesions greater than type 2 were rarely seen in the thoracic aorta. Although type 2 lesions appeared later in the LAD than in the aorta, the lesions within the LAD progressed rapidly to more advanced lesions (types 4 and 5) or atheroma. Lesion development in the abdominal aorta was intermediate to lesion development in the thoracic aorta and the LAD. Conclusions The most striking topographic difference on lesion progression among the three anatomical sites was the vulnerability of type 2 lesions to progress into advanced lesions. The histology study, including immunohistochemistry limited to the type 2 lesions suggested that lesion progression was related to the intimal thickness and the amount of collagen but not to the number of macrophage foam cells.</description><subject>Adolescence</subject><subject>Adolescent</subject><subject>Adult</subject><subject>African Americans</subject><subject>AHA classification</subject><subject>Aorta</subject><subject>Aorta, Abdominal - pathology</subject><subject>Aorta, Thoracic - pathology</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - classification</subject><subject>Atherosclerosis - pathology</subject><subject>Autopsy</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Collagen</subject><subject>Coronary arteries</subject><subject>Coronary Artery Disease - pathology</subject><subject>European Continental Ancestry Group</subject><subject>Fatty streaks</subject><subject>Female</subject><subject>Histology</subject><subject>Histometry</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intimal thickness</subject><subject>Macrophage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>PDAY</subject><subject>Prevalence</subject><subject>Sex Factors</subject><subject>Smooth muscle cells</subject><subject>T-lymphocytes</subject><subject>Topography</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Media - pathology</subject><subject>United States - epidemiology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Young people</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2P0zAQhiMEYsvCX0C5LLcU23Xs-MBKaAW7K63EAThbjjNpXVw7eJJK_fc42y4fPSFZtmw_885o3imKK0qWlFDxfrs04wZSROvn3eGSESKX82LyWbGgjVQV5Q1_XiwIYbRStCYXxSvELSGES9q8LC6obIRitVoU9s7hGH1cO2t8OcYhrpMZNo83G3eDSQ5jwDL25VneckiZBUQXQ-lCuZ32EJwHLE3oykOcwro03eRHfF286I1HeHM6L4vvnz99u7mrHr7c3t98fKgsV1JWqrYgQLS2YcoywWUNjPHW1m3dMyBK2sa0lEmSn9XKyLY2iq-UFaJvu8ysLovro-4wtTvoLIQxGa-H5HYmHXQ0Tv_7E9xGr-NeM6EEoTwLvDsJpPhzAhz1zqEF702AOKGWhHOqOM3ghyNocyswQf87CSV6tklv9Vm79GyTnheTOf7t35X-iT75koGrE2AwW9EnE2zWeOLYLKJ4nbnbIwe5r3sHSaN1ECx0LoEddRfdf5d0faZkvQvzHPyAA-A2Tilk8zTVyDTRX-fZmkeLyMepEqtfmlTUIg</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>Homma, Satoki</creator><creator>Troxclair, Dana A</creator><creator>Zieske, Arthur W</creator><creator>Malcom, Gray T</creator><creator>Strong, Jack P</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200804</creationdate><title>Histological topographical comparisons of atherosclerosis progression in juveniles and young adults</title><author>Homma, Satoki ; Troxclair, Dana A ; Zieske, Arthur W ; Malcom, Gray T ; Strong, Jack P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4977-95ce6e6bc829c26475e224bc5b5f2e097c8ab1270e2293a7b5a9439c66fbdb5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescence</topic><topic>Adolescent</topic><topic>Adult</topic><topic>African Americans</topic><topic>AHA classification</topic><topic>Aorta</topic><topic>Aorta, Abdominal - pathology</topic><topic>Aorta, Thoracic - pathology</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Atherosclerosis - classification</topic><topic>Atherosclerosis - pathology</topic><topic>Autopsy</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Collagen</topic><topic>Coronary arteries</topic><topic>Coronary Artery Disease - pathology</topic><topic>European Continental Ancestry Group</topic><topic>Fatty streaks</topic><topic>Female</topic><topic>Histology</topic><topic>Histometry</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Intimal thickness</topic><topic>Macrophage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>PDAY</topic><topic>Prevalence</topic><topic>Sex Factors</topic><topic>Smooth muscle cells</topic><topic>T-lymphocytes</topic><topic>Topography</topic><topic>Tunica Intima - pathology</topic><topic>Tunica Media - pathology</topic><topic>United States - epidemiology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Young people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Homma, Satoki</creatorcontrib><creatorcontrib>Troxclair, Dana A</creatorcontrib><creatorcontrib>Zieske, Arthur W</creatorcontrib><creatorcontrib>Malcom, Gray T</creatorcontrib><creatorcontrib>Strong, Jack P</creatorcontrib><creatorcontrib>for the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group</creatorcontrib><creatorcontrib>Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Homma, Satoki</au><au>Troxclair, Dana A</au><au>Zieske, Arthur W</au><au>Malcom, Gray T</au><au>Strong, Jack P</au><aucorp>for the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group</aucorp><aucorp>Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histological topographical comparisons of atherosclerosis progression in juveniles and young adults</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2008-04</date><risdate>2008</risdate><volume>197</volume><issue>2</issue><spage>791</spage><epage>798</epage><pages>791-798</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract Background The histologically topographic comparisons on atherosclerosis progression among three anatomical sites, mid-thoracic and lower abdominal aorta and left anterior descending coronary artery (LAD) were performed using a young population (age 15–34 years) from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Methods and results The histological classification based on the American Heart Association grading scheme showed that in the thoracic aorta type 2 lesions (numerous macrophage foam cells with fine particles but no pools of extracellular lipid) appeared in the first 10-year age group, with no significant change in prevalence in the next 10 years. Lesions greater than type 2 were rarely seen in the thoracic aorta. Although type 2 lesions appeared later in the LAD than in the aorta, the lesions within the LAD progressed rapidly to more advanced lesions (types 4 and 5) or atheroma. Lesion development in the abdominal aorta was intermediate to lesion development in the thoracic aorta and the LAD. Conclusions The most striking topographic difference on lesion progression among the three anatomical sites was the vulnerability of type 2 lesions to progress into advanced lesions. The histology study, including immunohistochemistry limited to the type 2 lesions suggested that lesion progression was related to the intimal thickness and the amount of collagen but not to the number of macrophage foam cells.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17869259</pmid><doi>10.1016/j.atherosclerosis.2007.07.027</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescence Adolescent Adult African Americans AHA classification Aorta Aorta, Abdominal - pathology Aorta, Thoracic - pathology Arteriosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - classification Atherosclerosis - pathology Autopsy Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Collagen Coronary arteries Coronary Artery Disease - pathology European Continental Ancestry Group Fatty streaks Female Histology Histometry Humans Immunohistochemistry Intimal thickness Macrophage Male Medical sciences Neurology PDAY Prevalence Sex Factors Smooth muscle cells T-lymphocytes Topography Tunica Intima - pathology Tunica Media - pathology United States - epidemiology Vascular diseases and vascular malformations of the nervous system Young people |
| title | Histological topographical comparisons of atherosclerosis progression in juveniles and young adults |
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