In vivo determination of multiple indices of periodontal inflammation by optical spectroscopy
Background and Objective: Visible, near‐infrared (optical) spectroscopy can be used to measure regional tissue hemodynamics and edema and therefore may represent an ideal tool with which to study periodontal inflammation in a noninvasive manner. The study objective was to evaluate the ability of op...
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| creator | Liu, K. Z. Xiang, X. M. Man, A. Sowa, M. G. Cholakis, A. Ghiabi, E. Singer, D. L. Scott, D. A. |
| description | Background and Objective: Visible, near‐infrared (optical) spectroscopy can be used to measure regional tissue hemodynamics and edema and therefore may represent an ideal tool with which to study periodontal inflammation in a noninvasive manner. The study objective was to evaluate the ability of optical spectroscopy to determine simultaneously multiple inflammatory indices (tissue oxygenation, total tissue hemoglobin, deoxyhemoglobin, oxygenated hemoglobin and tissue edema) in periodontal tissues in vivo.
Material and Methods: Spectra were obtained, processed and evaluated from healthy, gingivitis and periodontitis sites (n = 133) using a portable optical, near‐infrared spectrometer. A modified Beer–Lambert unmixing model that incorporates a nonparametric scattering loss function was used to determine the relative contribution of each inflammatory component to the overall spectrum.
Results: Optical spectroscopy was harnessed to generate complex inflammatory profiles of periodontal tissues. Tissue oxygenation at periodontitis sites was significantly decreased (p |
| doi_str_mv | 10.1111/j.1600-0765.2008.01112.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2695504</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67350653</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6702-782c30c5de0244cdfa76cf08017cd4c2a388f7425a5006b828ad020c7d3b0d003</originalsourceid><addsrcrecordid>eNqNUV1v0zAUtRCIlY2_gPICb8lunPijDyCxaV-sYhICDSEhy7UdcEnsYKdd--9xSFXgDb_YPvec4-t7EMpKKMq0TldFSQFyYJQUGIAXkFBcbB-h2aHwGM0AMM6rmtdH6FmMK0h3yuZP0VHJ56wiFZ-hrzcu29iNz7QZTOisk4P1LvNN1q3bwfatyazTVpk4Yr0J1mvvBtkmuGll10385S7z_WBVwmNv1BB8VL7fnaAnjWyjeb7fj9Gny4uP59f54u7q5vztIleUAc4Zx6oCRbQBXNdKN5JR1QCHkildKywrzhtWYyIJAF1yzKUGDIrpagkaoDpGbybffr3sjFbGDUG2og-2k2EnvLTi34qz38U3vxGYzgmBOhm82hsE_3Nt4iA6G5VpW-mMX0dB07iAkioR-URU6YsxmObwSAlizEasxBiBGCMQYzbidzZim6Qv_m7yj3AfRiK83BNkTJNsgnTKxgMPl8kJM5x4ryfeg23N7r8bEO8-XIynpM8nvY2D2R70MvwY_8mIuH9_JRb151t-dv9FXFa_AHRcu8g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67350653</pqid></control><display><type>article</type><title>In vivo determination of multiple indices of periodontal inflammation by optical spectroscopy</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Liu, K. Z. ; Xiang, X. M. ; Man, A. ; Sowa, M. G. ; Cholakis, A. ; Ghiabi, E. ; Singer, D. L. ; Scott, D. A.</creator><creatorcontrib>Liu, K. Z. ; Xiang, X. M. ; Man, A. ; Sowa, M. G. ; Cholakis, A. ; Ghiabi, E. ; Singer, D. L. ; Scott, D. A.</creatorcontrib><description>Background and Objective: Visible, near‐infrared (optical) spectroscopy can be used to measure regional tissue hemodynamics and edema and therefore may represent an ideal tool with which to study periodontal inflammation in a noninvasive manner. The study objective was to evaluate the ability of optical spectroscopy to determine simultaneously multiple inflammatory indices (tissue oxygenation, total tissue hemoglobin, deoxyhemoglobin, oxygenated hemoglobin and tissue edema) in periodontal tissues in vivo.
Material and Methods: Spectra were obtained, processed and evaluated from healthy, gingivitis and periodontitis sites (n = 133) using a portable optical, near‐infrared spectrometer. A modified Beer–Lambert unmixing model that incorporates a nonparametric scattering loss function was used to determine the relative contribution of each inflammatory component to the overall spectrum.
Results: Optical spectroscopy was harnessed to generate complex inflammatory profiles of periodontal tissues. Tissue oxygenation at periodontitis sites was significantly decreased (p < 0.05) compared to sites with gingivitis and healthy controls. This was largely the result of an increase in deoxyhemoglobin in the periodontitis sites compared with healthy (p < 0.01) and gingivitis (p = 0.05) sites. Tissue water content per se showed no significant difference between the sites, but a water index associated with tissue electrolyte levels and temperature differed significantly between periodontitis sites and both healthy and gingivitis sites (p < 0.03).
Conclusion: This study established that optical spectroscopy can simultaneously determine multiple inflammatory indices directly in the periodontal tissues in vivo. Visible, near‐infrared spectroscopy has the potential to be developed into a simple, reagent‐free, user‐friendly, chairside, site‐specific, diagnostic and prognostic test for periodontitis.</description><identifier>ISSN: 0022-3484</identifier><identifier>EISSN: 1600-0765</identifier><identifier>DOI: 10.1111/j.1600-0765.2008.01112.x</identifier><identifier>PMID: 18973538</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Body Temperature - physiology ; Body Water - chemistry ; Chronic Periodontitis - blood ; Chronic Periodontitis - diagnosis ; Chronic Periodontitis - pathology ; Dentistry ; edema ; Edema - blood ; Edema - diagnosis ; Edema - pathology ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Gingival Hemorrhage - pathology ; Gingivitis - blood ; Gingivitis - diagnosis ; Gingivitis - pathology ; Hemoglobins - analysis ; Humans ; inflammation ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases ; optical spectroscopy ; Otorhinolaryngology. Stomatology ; Oxygen Consumption - physiology ; Oxyhemoglobins - analysis ; Periodontal Attachment Loss - pathology ; Periodontal Index ; Periodontal Pocket - pathology ; periodontitis ; Periodontium - metabolism ; Periodontium - pathology ; Spectroscopy, Near-Infrared - methods ; tissue oxygenation ; Water-Electrolyte Balance - physiology</subject><ispartof>Journal of periodontal research, 2009-02, Vol.44 (1), p.117-124</ispartof><rights>2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6702-782c30c5de0244cdfa76cf08017cd4c2a388f7425a5006b828ad020c7d3b0d003</citedby><cites>FETCH-LOGICAL-c6702-782c30c5de0244cdfa76cf08017cd4c2a388f7425a5006b828ad020c7d3b0d003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0765.2008.01112.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0765.2008.01112.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21011272$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18973538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, K. Z.</creatorcontrib><creatorcontrib>Xiang, X. M.</creatorcontrib><creatorcontrib>Man, A.</creatorcontrib><creatorcontrib>Sowa, M. G.</creatorcontrib><creatorcontrib>Cholakis, A.</creatorcontrib><creatorcontrib>Ghiabi, E.</creatorcontrib><creatorcontrib>Singer, D. L.</creatorcontrib><creatorcontrib>Scott, D. A.</creatorcontrib><title>In vivo determination of multiple indices of periodontal inflammation by optical spectroscopy</title><title>Journal of periodontal research</title><addtitle>J Periodontal Res</addtitle><description>Background and Objective: Visible, near‐infrared (optical) spectroscopy can be used to measure regional tissue hemodynamics and edema and therefore may represent an ideal tool with which to study periodontal inflammation in a noninvasive manner. The study objective was to evaluate the ability of optical spectroscopy to determine simultaneously multiple inflammatory indices (tissue oxygenation, total tissue hemoglobin, deoxyhemoglobin, oxygenated hemoglobin and tissue edema) in periodontal tissues in vivo.
Material and Methods: Spectra were obtained, processed and evaluated from healthy, gingivitis and periodontitis sites (n = 133) using a portable optical, near‐infrared spectrometer. A modified Beer–Lambert unmixing model that incorporates a nonparametric scattering loss function was used to determine the relative contribution of each inflammatory component to the overall spectrum.
Results: Optical spectroscopy was harnessed to generate complex inflammatory profiles of periodontal tissues. Tissue oxygenation at periodontitis sites was significantly decreased (p < 0.05) compared to sites with gingivitis and healthy controls. This was largely the result of an increase in deoxyhemoglobin in the periodontitis sites compared with healthy (p < 0.01) and gingivitis (p = 0.05) sites. Tissue water content per se showed no significant difference between the sites, but a water index associated with tissue electrolyte levels and temperature differed significantly between periodontitis sites and both healthy and gingivitis sites (p < 0.03).
Conclusion: This study established that optical spectroscopy can simultaneously determine multiple inflammatory indices directly in the periodontal tissues in vivo. Visible, near‐infrared spectroscopy has the potential to be developed into a simple, reagent‐free, user‐friendly, chairside, site‐specific, diagnostic and prognostic test for periodontitis.</description><subject>Biological and medical sciences</subject><subject>Body Temperature - physiology</subject><subject>Body Water - chemistry</subject><subject>Chronic Periodontitis - blood</subject><subject>Chronic Periodontitis - diagnosis</subject><subject>Chronic Periodontitis - pathology</subject><subject>Dentistry</subject><subject>edema</subject><subject>Edema - blood</subject><subject>Edema - diagnosis</subject><subject>Edema - pathology</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Gingival Hemorrhage - pathology</subject><subject>Gingivitis - blood</subject><subject>Gingivitis - diagnosis</subject><subject>Gingivitis - pathology</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>inflammation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>optical spectroscopy</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Oxygen Consumption - physiology</subject><subject>Oxyhemoglobins - analysis</subject><subject>Periodontal Attachment Loss - pathology</subject><subject>Periodontal Index</subject><subject>Periodontal Pocket - pathology</subject><subject>periodontitis</subject><subject>Periodontium - metabolism</subject><subject>Periodontium - pathology</subject><subject>Spectroscopy, Near-Infrared - methods</subject><subject>tissue oxygenation</subject><subject>Water-Electrolyte Balance - physiology</subject><issn>0022-3484</issn><issn>1600-0765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUV1v0zAUtRCIlY2_gPICb8lunPijDyCxaV-sYhICDSEhy7UdcEnsYKdd--9xSFXgDb_YPvec4-t7EMpKKMq0TldFSQFyYJQUGIAXkFBcbB-h2aHwGM0AMM6rmtdH6FmMK0h3yuZP0VHJ56wiFZ-hrzcu29iNz7QZTOisk4P1LvNN1q3bwfatyazTVpk4Yr0J1mvvBtkmuGll10385S7z_WBVwmNv1BB8VL7fnaAnjWyjeb7fj9Gny4uP59f54u7q5vztIleUAc4Zx6oCRbQBXNdKN5JR1QCHkildKywrzhtWYyIJAF1yzKUGDIrpagkaoDpGbybffr3sjFbGDUG2og-2k2EnvLTi34qz38U3vxGYzgmBOhm82hsE_3Nt4iA6G5VpW-mMX0dB07iAkioR-URU6YsxmObwSAlizEasxBiBGCMQYzbidzZim6Qv_m7yj3AfRiK83BNkTJNsgnTKxgMPl8kJM5x4ryfeg23N7r8bEO8-XIynpM8nvY2D2R70MvwY_8mIuH9_JRb151t-dv9FXFa_AHRcu8g</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Liu, K. Z.</creator><creator>Xiang, X. M.</creator><creator>Man, A.</creator><creator>Sowa, M. G.</creator><creator>Cholakis, A.</creator><creator>Ghiabi, E.</creator><creator>Singer, D. L.</creator><creator>Scott, D. A.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200902</creationdate><title>In vivo determination of multiple indices of periodontal inflammation by optical spectroscopy</title><author>Liu, K. Z. ; Xiang, X. M. ; Man, A. ; Sowa, M. G. ; Cholakis, A. ; Ghiabi, E. ; Singer, D. L. ; Scott, D. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6702-782c30c5de0244cdfa76cf08017cd4c2a388f7425a5006b828ad020c7d3b0d003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Body Temperature - physiology</topic><topic>Body Water - chemistry</topic><topic>Chronic Periodontitis - blood</topic><topic>Chronic Periodontitis - diagnosis</topic><topic>Chronic Periodontitis - pathology</topic><topic>Dentistry</topic><topic>edema</topic><topic>Edema - blood</topic><topic>Edema - diagnosis</topic><topic>Edema - pathology</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Gingival Hemorrhage - pathology</topic><topic>Gingivitis - blood</topic><topic>Gingivitis - diagnosis</topic><topic>Gingivitis - pathology</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>inflammation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>optical spectroscopy</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Oxygen Consumption - physiology</topic><topic>Oxyhemoglobins - analysis</topic><topic>Periodontal Attachment Loss - pathology</topic><topic>Periodontal Index</topic><topic>Periodontal Pocket - pathology</topic><topic>periodontitis</topic><topic>Periodontium - metabolism</topic><topic>Periodontium - pathology</topic><topic>Spectroscopy, Near-Infrared - methods</topic><topic>tissue oxygenation</topic><topic>Water-Electrolyte Balance - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, K. Z.</creatorcontrib><creatorcontrib>Xiang, X. M.</creatorcontrib><creatorcontrib>Man, A.</creatorcontrib><creatorcontrib>Sowa, M. G.</creatorcontrib><creatorcontrib>Cholakis, A.</creatorcontrib><creatorcontrib>Ghiabi, E.</creatorcontrib><creatorcontrib>Singer, D. L.</creatorcontrib><creatorcontrib>Scott, D. A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of periodontal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, K. Z.</au><au>Xiang, X. M.</au><au>Man, A.</au><au>Sowa, M. G.</au><au>Cholakis, A.</au><au>Ghiabi, E.</au><au>Singer, D. L.</au><au>Scott, D. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo determination of multiple indices of periodontal inflammation by optical spectroscopy</atitle><jtitle>Journal of periodontal research</jtitle><addtitle>J Periodontal Res</addtitle><date>2009-02</date><risdate>2009</risdate><volume>44</volume><issue>1</issue><spage>117</spage><epage>124</epage><pages>117-124</pages><issn>0022-3484</issn><eissn>1600-0765</eissn><abstract>Background and Objective: Visible, near‐infrared (optical) spectroscopy can be used to measure regional tissue hemodynamics and edema and therefore may represent an ideal tool with which to study periodontal inflammation in a noninvasive manner. The study objective was to evaluate the ability of optical spectroscopy to determine simultaneously multiple inflammatory indices (tissue oxygenation, total tissue hemoglobin, deoxyhemoglobin, oxygenated hemoglobin and tissue edema) in periodontal tissues in vivo.
Material and Methods: Spectra were obtained, processed and evaluated from healthy, gingivitis and periodontitis sites (n = 133) using a portable optical, near‐infrared spectrometer. A modified Beer–Lambert unmixing model that incorporates a nonparametric scattering loss function was used to determine the relative contribution of each inflammatory component to the overall spectrum.
Results: Optical spectroscopy was harnessed to generate complex inflammatory profiles of periodontal tissues. Tissue oxygenation at periodontitis sites was significantly decreased (p < 0.05) compared to sites with gingivitis and healthy controls. This was largely the result of an increase in deoxyhemoglobin in the periodontitis sites compared with healthy (p < 0.01) and gingivitis (p = 0.05) sites. Tissue water content per se showed no significant difference between the sites, but a water index associated with tissue electrolyte levels and temperature differed significantly between periodontitis sites and both healthy and gingivitis sites (p < 0.03).
Conclusion: This study established that optical spectroscopy can simultaneously determine multiple inflammatory indices directly in the periodontal tissues in vivo. Visible, near‐infrared spectroscopy has the potential to be developed into a simple, reagent‐free, user‐friendly, chairside, site‐specific, diagnostic and prognostic test for periodontitis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18973538</pmid><doi>10.1111/j.1600-0765.2008.01112.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Body Temperature - physiology Body Water - chemistry Chronic Periodontitis - blood Chronic Periodontitis - diagnosis Chronic Periodontitis - pathology Dentistry edema Edema - blood Edema - diagnosis Edema - pathology Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Gingival Hemorrhage - pathology Gingivitis - blood Gingivitis - diagnosis Gingivitis - pathology Hemoglobins - analysis Humans inflammation Male Medical sciences Middle Aged Non tumoral diseases optical spectroscopy Otorhinolaryngology. Stomatology Oxygen Consumption - physiology Oxyhemoglobins - analysis Periodontal Attachment Loss - pathology Periodontal Index Periodontal Pocket - pathology periodontitis Periodontium - metabolism Periodontium - pathology Spectroscopy, Near-Infrared - methods tissue oxygenation Water-Electrolyte Balance - physiology |
| title | In vivo determination of multiple indices of periodontal inflammation by optical spectroscopy |
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