Potential therapeutic applications of hyaluronan in the lung
Hyaluronan (HA), a long-chain polysaccharide, is currently being evaluated as a potential therapeutic agent for a number of inflammatory disorders. The effect of HA on inflammation appears to be related to its molecular size, with larger polysaccharide chains having anti-inflammatory activity and sm...
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| Veröffentlicht in: | International journal of chronic obstructive pulmonary disease 2007, Vol.2 (3), p.283-288 |
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| container_title | International journal of chronic obstructive pulmonary disease |
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| creator | Cantor, Jerome O |
| description | Hyaluronan (HA), a long-chain polysaccharide, is currently being evaluated as a potential therapeutic agent for a number of inflammatory disorders. The effect of HA on inflammation appears to be related to its molecular size, with larger polysaccharide chains having anti-inflammatory activity and smaller ones having proinflammatory properties. This dichotomous behavior is particularly relevant to the work of our laboratory on an aerosolized preparation of HA to treat pulmonary emphysema. The breakdown of inhaled HA into smaller fragments could possibly induce an inflammatory reaction in the lung that counteracts any beneficial effect. Consequently, the proposed therapeutic use of HA will require development of treatment strategies aimed at minimizing its proinflammatory activity. |
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The effect of HA on inflammation appears to be related to its molecular size, with larger polysaccharide chains having anti-inflammatory activity and smaller ones having proinflammatory properties. This dichotomous behavior is particularly relevant to the work of our laboratory on an aerosolized preparation of HA to treat pulmonary emphysema. The breakdown of inhaled HA into smaller fragments could possibly induce an inflammatory reaction in the lung that counteracts any beneficial effect. 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| identifier | ISSN: 1176-9106 |
| ispartof | International journal of chronic obstructive pulmonary disease, 2007, Vol.2 (3), p.283-288 |
| issn | 1176-9106 1178-2005 |
| language | eng |
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| source | Taylor & Francis Open Access; MEDLINE; DOVE Medical Press Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Humans Hyaluronic Acid - administration & dosage Hyaluronic Acid - pharmacology Hyaluronic Acid - therapeutic use Pneumonia - drug therapy Pulmonary Disease, Chronic Obstructive Review |
| title | Potential therapeutic applications of hyaluronan in the lung |
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