A case of asymptomatic intraductal papillary neoplasm of the bile duct without hepatolithiasis
A 65-year-old woman was found to have dilatation of the intrahepatic bile duct in the right anterior segment during a general health. Laboratory data were within normal ranges and no solid mass was detected in her abdominal computer tomography （CT） or nuclear magnetic resonance imaging （MRI）. Howeve...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2008-03, Vol.14 (10), p.1625-1629 |
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| creator | Hayashi, Junpei Matsuoka, Shyunichi Inami, Makiko Ohshiro, Shu Ishigami, Akiyasu Fujikawa, Hirotoshi Miyagawa, Masahide Mimatsu, Kenji Kuboi, Youichi Kanou, Hisao Oida, Takatsugu Moriyama, Mitsuhiko |
| description | A 65-year-old woman was found to have dilatation of the intrahepatic bile duct in the right anterior segment during a general health. Laboratory data were within normal ranges and no solid mass was detected in her abdominal computer tomography （CT） or nuclear magnetic resonance imaging （MRI）. However, endoscopic retrograde cholangiopancreatography （ERCP） demonstrated an obstruction of the right bile duct. Intraoperative cholangiography showed stenosis of the intrahepatic bile duct in the anterior inferior segment （B5） and narrowness of the intrahepatic bile duct in the anterior superior segment （B8）, so that we strongly suspected intrahepatic cholangiocarcinoma （ICC）. Histologically, surgically resected liver specimens, without tumor mass by macroscopic observation, showed intraductal papillary proliferation with fibrovascular cores and intraductal spreading of carcinoma in situ throughout a considerable area, especially in bile ductules around the peripheral small portal area. Furthermore, the immunohistochemical profile of the tumor （MUC5AC＋/CK7＋） was compatible with an intraductal papillary neoplasm of the bile duct （IPN-B）. Consequently, this case was diagnosed as IPN-B with spreading CIS, stageⅠ（pT1, pN0, P0, H1, M0）. We report a case of IPN-B with interesting histopathologicalfindings and emphasize that cholangiography is especially helpful for the diagnosis of bile duct dilatation due to infiltration of carcinoma cells. |
| doi_str_mv | 10.3748/wjg.14.1625 |
| format | Article |
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Laboratory data were within normal ranges and no solid mass was detected in her abdominal computer tomography （CT） or nuclear magnetic resonance imaging （MRI）. However, endoscopic retrograde cholangiopancreatography （ERCP） demonstrated an obstruction of the right bile duct. Intraoperative cholangiography showed stenosis of the intrahepatic bile duct in the anterior inferior segment （B5） and narrowness of the intrahepatic bile duct in the anterior superior segment （B8）, so that we strongly suspected intrahepatic cholangiocarcinoma （ICC）. Histologically, surgically resected liver specimens, without tumor mass by macroscopic observation, showed intraductal papillary proliferation with fibrovascular cores and intraductal spreading of carcinoma in situ throughout a considerable area, especially in bile ductules around the peripheral small portal area. Furthermore, the immunohistochemical profile of the tumor （MUC5AC＋/CK7＋） was compatible with an intraductal papillary neoplasm of the bile duct （IPN-B）. Consequently, this case was diagnosed as IPN-B with spreading CIS, stageⅠ（pT1, pN0, P0, H1, M0）. We report a case of IPN-B with interesting histopathologicalfindings and emphasize that cholangiography is especially helpful for the diagnosis of bile duct dilatation due to infiltration of carcinoma cells.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.14.1625</identifier><identifier>PMID: 18330960</identifier><language>eng</language><publisher>United States: Division of Gastroenterology and Hepatology,Department of Medicine,Nihon University School of Medicine,Tokyo 173-8610,Japan%Department of Gastroenterology,Social Insurance Yokohama Central Hospital,Yokohama 231-8553,Japan%Department of Surgery,Social Insurance Yokohama Central Hospital,Yokohama 231-8553,Japan%Division of Gastroenterology and Hepatology,Department of Medicine,Nihon University School of Medicine,Tokyo 173-8610,Japan</publisher><subject>Aged ; Bile Duct Neoplasms - diagnosis ; Bile Duct Neoplasms - surgery ; Carcinoma, Intraductal, Noninfiltrating - diagnosis ; Carcinoma, Intraductal, Noninfiltrating - surgery ; Carcinoma, Papillary - diagnosis ; Carcinoma, Papillary - surgery ; Case Report ; Cholangiography ; Female ; Hepatectomy ; Humans ; Lithiasis ; Liver Diseases ; 管内突状瘤 ; 肝内胆管癌 ; 肝切除术 ; 肝结石</subject><ispartof>World journal of gastroenterology : WJG, 2008-03, Vol.14 (10), p.1625-1629</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2008 The WJG Press and Baishideng. All rights reserved. 2008</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-4a35ae3eff618f9dab6873c82b644a7a95fbedc1f49757d4f1316795ee6468c73</citedby><cites>FETCH-LOGICAL-c435t-4a35ae3eff618f9dab6873c82b644a7a95fbedc1f49757d4f1316795ee6468c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693764/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693764/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18330960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayashi, Junpei</creatorcontrib><creatorcontrib>Matsuoka, Shyunichi</creatorcontrib><creatorcontrib>Inami, Makiko</creatorcontrib><creatorcontrib>Ohshiro, Shu</creatorcontrib><creatorcontrib>Ishigami, Akiyasu</creatorcontrib><creatorcontrib>Fujikawa, Hirotoshi</creatorcontrib><creatorcontrib>Miyagawa, Masahide</creatorcontrib><creatorcontrib>Mimatsu, Kenji</creatorcontrib><creatorcontrib>Kuboi, Youichi</creatorcontrib><creatorcontrib>Kanou, Hisao</creatorcontrib><creatorcontrib>Oida, Takatsugu</creatorcontrib><creatorcontrib>Moriyama, Mitsuhiko</creatorcontrib><title>A case of asymptomatic intraductal papillary neoplasm of the bile duct without hepatolithiasis</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>A 65-year-old woman was found to have dilatation of the intrahepatic bile duct in the right anterior segment during a general health. Laboratory data were within normal ranges and no solid mass was detected in her abdominal computer tomography （CT） or nuclear magnetic resonance imaging （MRI）. However, endoscopic retrograde cholangiopancreatography （ERCP） demonstrated an obstruction of the right bile duct. Intraoperative cholangiography showed stenosis of the intrahepatic bile duct in the anterior inferior segment （B5） and narrowness of the intrahepatic bile duct in the anterior superior segment （B8）, so that we strongly suspected intrahepatic cholangiocarcinoma （ICC）. Histologically, surgically resected liver specimens, without tumor mass by macroscopic observation, showed intraductal papillary proliferation with fibrovascular cores and intraductal spreading of carcinoma in situ throughout a considerable area, especially in bile ductules around the peripheral small portal area. Furthermore, the immunohistochemical profile of the tumor （MUC5AC＋/CK7＋） was compatible with an intraductal papillary neoplasm of the bile duct （IPN-B）. Consequently, this case was diagnosed as IPN-B with spreading CIS, stageⅠ（pT1, pN0, P0, H1, M0）. We report a case of IPN-B with interesting histopathologicalfindings and emphasize that cholangiography is especially helpful for the diagnosis of bile duct dilatation due to infiltration of carcinoma cells.</description><subject>Aged</subject><subject>Bile Duct Neoplasms - diagnosis</subject><subject>Bile Duct Neoplasms - surgery</subject><subject>Carcinoma, Intraductal, Noninfiltrating - diagnosis</subject><subject>Carcinoma, Intraductal, Noninfiltrating - surgery</subject><subject>Carcinoma, Papillary - diagnosis</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Case Report</subject><subject>Cholangiography</subject><subject>Female</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Lithiasis</subject><subject>Liver Diseases</subject><subject>管内突状瘤</subject><subject>肝内胆管癌</subject><subject>肝切除术</subject><subject>肝结石</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd2L1DAUxYMo7uzqk-8SRHyRjvlqkr4sLIurwoIv-mq4zSTTjG3TbVKH_e9NmcGPp0u4P849OQehV5RsuRL6w_Gw31KxpZLVT9CGMdpUTAvyFG0oIapqOFMX6DKlAyGM85o9RxdUc04aSTboxw22kByOHkN6HKYcB8jB4jDmGXaLzdDjCabQ9zA_4tHFqYc0rHjuHG5D7_BK4WPIXVwy7twEOfblFSCF9AI989An9_I8r9D3u4_fbj9X918_fbm9ua-s4HWuBPAaHHfeS6p9s4NWasWtZq0UAhQ0tW_dzlIvGlWrnfCUU6ma2jkppLaKX6Hrk-60tEMh3Wq_N9MchuLbRAjm_80YOrOPvwyTDVdSFIG3J4EjjB7GvTnEZR6LZVPiZYTokiVb77w735njw-JSNkNI1pV0SjRLMopwLSVfwfcn0M4xpdn5P14oMWttq66hwqy1Ffr1v_b_sueeCvDmLNfFcf8QisEW7E9f8i9fUKVvqvhvmeehDg</recordid><startdate>20080314</startdate><enddate>20080314</enddate><creator>Hayashi, Junpei</creator><creator>Matsuoka, Shyunichi</creator><creator>Inami, Makiko</creator><creator>Ohshiro, Shu</creator><creator>Ishigami, Akiyasu</creator><creator>Fujikawa, Hirotoshi</creator><creator>Miyagawa, Masahide</creator><creator>Mimatsu, Kenji</creator><creator>Kuboi, Youichi</creator><creator>Kanou, Hisao</creator><creator>Oida, Takatsugu</creator><creator>Moriyama, Mitsuhiko</creator><general>Division of Gastroenterology and Hepatology,Department of Medicine,Nihon University School of Medicine,Tokyo 173-8610,Japan%Department of Gastroenterology,Social Insurance Yokohama Central Hospital,Yokohama 231-8553,Japan%Department of Surgery,Social Insurance Yokohama Central Hospital,Yokohama 231-8553,Japan%Division of Gastroenterology and Hepatology,Department of Medicine,Nihon University School of Medicine,Tokyo 173-8610,Japan</general><general>Department of Gastroenterology,Social Insurance Yokohama Central Hospital,Yokohama 231-8553,Japan</general><general>The WJG Press and Baishideng</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20080314</creationdate><title>A case of asymptomatic intraductal papillary neoplasm of the bile duct without hepatolithiasis</title><author>Hayashi, Junpei ; 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Laboratory data were within normal ranges and no solid mass was detected in her abdominal computer tomography （CT） or nuclear magnetic resonance imaging （MRI）. However, endoscopic retrograde cholangiopancreatography （ERCP） demonstrated an obstruction of the right bile duct. Intraoperative cholangiography showed stenosis of the intrahepatic bile duct in the anterior inferior segment （B5） and narrowness of the intrahepatic bile duct in the anterior superior segment （B8）, so that we strongly suspected intrahepatic cholangiocarcinoma （ICC）. Histologically, surgically resected liver specimens, without tumor mass by macroscopic observation, showed intraductal papillary proliferation with fibrovascular cores and intraductal spreading of carcinoma in situ throughout a considerable area, especially in bile ductules around the peripheral small portal area. Furthermore, the immunohistochemical profile of the tumor （MUC5AC＋/CK7＋） was compatible with an intraductal papillary neoplasm of the bile duct （IPN-B）. Consequently, this case was diagnosed as IPN-B with spreading CIS, stageⅠ（pT1, pN0, P0, H1, M0）. We report a case of IPN-B with interesting histopathologicalfindings and emphasize that cholangiography is especially helpful for the diagnosis of bile duct dilatation due to infiltration of carcinoma cells.</abstract><cop>United States</cop><pub>Division of Gastroenterology and Hepatology,Department of Medicine,Nihon University School of Medicine,Tokyo 173-8610,Japan%Department of Gastroenterology,Social Insurance Yokohama Central Hospital,Yokohama 231-8553,Japan%Department of Surgery,Social Insurance Yokohama Central Hospital,Yokohama 231-8553,Japan%Division of Gastroenterology and Hepatology,Department of Medicine,Nihon University School of Medicine,Tokyo 173-8610,Japan</pub><pmid>18330960</pmid><doi>10.3748/wjg.14.1625</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1007-9327 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aged Bile Duct Neoplasms - diagnosis Bile Duct Neoplasms - surgery Carcinoma, Intraductal, Noninfiltrating - diagnosis Carcinoma, Intraductal, Noninfiltrating - surgery Carcinoma, Papillary - diagnosis Carcinoma, Papillary - surgery Case Report Cholangiography Female Hepatectomy Humans Lithiasis Liver Diseases 管内突状瘤 肝内胆管癌 肝切除术 肝结石 |
| title | A case of asymptomatic intraductal papillary neoplasm of the bile duct without hepatolithiasis |
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