MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinases

AIM：To investigate the anti-neoplastic effect of MK615, an anti-neoplastic compound isolated from Japanese apricot, against human pancreatic cancer cells in vitro. METHODS： Three human pancreatic cancer cell lines PANC-1, PK-1, and PK45H were cultured with MK615 at concentrations of 600, 300, 150, a...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2008-03, Vol.14 (9), p.1378-1382
Hauptverfasser:	Okada, Toshie, Sawada, Tokihiko, Osawa, Tatsushi, Adachi, Masakazu, Kubota, Keiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Antineoplastic Agents - pharmacology Aurora Kinases Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Humans Pancreatic Neoplasms - pathology Plant Extracts - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Prunus Rapid Communication Signal Transduction - drug effects 细胞周期细胞生长抑制胰腺癌
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