The Role of Robo3 in the Development of Cortical Interneurons
A number of studies in recent years have shown that members of the Roundabout (Robo) receptor family, Robo1 and Robo2, play significant roles in the formation of axonal tracks in the developing forebrain and in the migration and morphological differentiation of cortical interneurons. Here, we invest...
Gespeichert in:
| Veröffentlicht in: | Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2009-07, Vol.19 (suppl-1), p.i22-i31 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | i31 |
|---|---|
| container_issue | suppl-1 |
| container_start_page | i22 |
| container_title | Cerebral cortex (New York, N.Y. 1991) |
| container_volume | 19 |
| creator | Barber, Melissa Di Meglio, Thomas Andrews, William D. Hernández-Miranda, Luis R. Murakami, Fujio Chédotal, Alain Parnavelas, John G. |
| description | A number of studies in recent years have shown that members of the Roundabout (Robo) receptor family, Robo1 and Robo2, play significant roles in the formation of axonal tracks in the developing forebrain and in the migration and morphological differentiation of cortical interneurons. Here, we investigated the expression and function of Robo3 in the developing cortex. We found that this receptor is strongly expressed in the preplate layer and cortical hem of the early cortex where it colocalizes with markers of Cajal–Retzius cells and interneurons. Analysis of Robo3 mutant mice at early (embryonic day [E] 13.5) and late (E18.5) stages of corticogenesis revealed no significant change in the number of interneurons, but a change in their morphology at E13.5. However, preliminary analysis on a small number of mice that lacked all 3 Robo receptors indicated a marked reduction in the number of cortical interneurons, but only a limited effect on their morphology. These observations and the results of other recent studies suggest a complex interplay between the 3 Robo receptors in regulating the number, migration and morphological differentiation of cortical interneurons. |
| doi_str_mv | 10.1093/cercor/bhp041 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2693537</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67351349</sourcerecordid><originalsourceid>FETCH-LOGICAL-c522t-37b47fe94566ae8e50f21dbcfc8d8ab7b00e5527f6f022f66134411da96156dd3</originalsourceid><addsrcrecordid>eNp9kUtLAzEUhYMoPqpLtzIrcTOaxyRpFgpSHxWLQqkgbkImc2NHp5OaTIv-e6e0WN24uuGej3NPOAgdEnxKsGJnFoL14SwfT3FGNtAuyQROKVFqs33jTKaMErKD9mJ8w5hIyuk22iGKCdEVahedj8aQDH0FiXftzD1Lyjpp2uUVzKHy0wnUzULr-dCU1lTJXd1AqGEWfB330ZYzVYSD1eygp5vrUa-fDh5v73qXg9RySpuUyTyTDlTGhTDQBY4dJUVune0WXZPLHGPgnEonHKbUCUFYlhFSGCUIF0XBOuhi6Tud5RMobJspmEpPQzkx4Ut7U-q_Sl2O9aufayoU40y2Bscrg-A_ZhAbPSmjhaoyNfhZ1EIy3h5VLXjyL0gyRQWjC7qD0iVqg48xgPvJQ7BedKOX3ehlNy1_9PsTa3pVxtqwjA18_ugmvC_ySa77zy962O_fD0YY6wf2Daktm4Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1492632351</pqid></control><display><type>article</type><title>The Role of Robo3 in the Development of Cortical Interneurons</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Barber, Melissa ; Di Meglio, Thomas ; Andrews, William D. ; Hernández-Miranda, Luis R. ; Murakami, Fujio ; Chédotal, Alain ; Parnavelas, John G.</creator><creatorcontrib>Barber, Melissa ; Di Meglio, Thomas ; Andrews, William D. ; Hernández-Miranda, Luis R. ; Murakami, Fujio ; Chédotal, Alain ; Parnavelas, John G.</creatorcontrib><description>A number of studies in recent years have shown that members of the Roundabout (Robo) receptor family, Robo1 and Robo2, play significant roles in the formation of axonal tracks in the developing forebrain and in the migration and morphological differentiation of cortical interneurons. Here, we investigated the expression and function of Robo3 in the developing cortex. We found that this receptor is strongly expressed in the preplate layer and cortical hem of the early cortex where it colocalizes with markers of Cajal–Retzius cells and interneurons. Analysis of Robo3 mutant mice at early (embryonic day [E] 13.5) and late (E18.5) stages of corticogenesis revealed no significant change in the number of interneurons, but a change in their morphology at E13.5. However, preliminary analysis on a small number of mice that lacked all 3 Robo receptors indicated a marked reduction in the number of cortical interneurons, but only a limited effect on their morphology. These observations and the results of other recent studies suggest a complex interplay between the 3 Robo receptors in regulating the number, migration and morphological differentiation of cortical interneurons.</description><identifier>ISSN: 1047-3211</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhp041</identifier><identifier>PMID: 19366869</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Animals ; Cell Differentiation ; Cerebral Cortex - cytology ; Cerebral Cortex - embryology ; Cerebral Cortex - pathology ; interneuron ; Interneurons - cytology ; Interneurons - physiology ; Membrane Proteins - metabolism ; Mice ; morphology ; Nerve Tissue Proteins - metabolism ; Prosencephalon - cytology ; Prosencephalon - embryology ; Prosencephalon - physiology ; Robo ; Signal Transduction - physiology</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2009-07, Vol.19 (suppl-1), p.i22-i31</ispartof><rights>2009 The Authors 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-37b47fe94566ae8e50f21dbcfc8d8ab7b00e5527f6f022f66134411da96156dd3</citedby><cites>FETCH-LOGICAL-c522t-37b47fe94566ae8e50f21dbcfc8d8ab7b00e5527f6f022f66134411da96156dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19366869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barber, Melissa</creatorcontrib><creatorcontrib>Di Meglio, Thomas</creatorcontrib><creatorcontrib>Andrews, William D.</creatorcontrib><creatorcontrib>Hernández-Miranda, Luis R.</creatorcontrib><creatorcontrib>Murakami, Fujio</creatorcontrib><creatorcontrib>Chédotal, Alain</creatorcontrib><creatorcontrib>Parnavelas, John G.</creatorcontrib><title>The Role of Robo3 in the Development of Cortical Interneurons</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>A number of studies in recent years have shown that members of the Roundabout (Robo) receptor family, Robo1 and Robo2, play significant roles in the formation of axonal tracks in the developing forebrain and in the migration and morphological differentiation of cortical interneurons. Here, we investigated the expression and function of Robo3 in the developing cortex. We found that this receptor is strongly expressed in the preplate layer and cortical hem of the early cortex where it colocalizes with markers of Cajal–Retzius cells and interneurons. Analysis of Robo3 mutant mice at early (embryonic day [E] 13.5) and late (E18.5) stages of corticogenesis revealed no significant change in the number of interneurons, but a change in their morphology at E13.5. However, preliminary analysis on a small number of mice that lacked all 3 Robo receptors indicated a marked reduction in the number of cortical interneurons, but only a limited effect on their morphology. These observations and the results of other recent studies suggest a complex interplay between the 3 Robo receptors in regulating the number, migration and morphological differentiation of cortical interneurons.</description><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - embryology</subject><subject>Cerebral Cortex - pathology</subject><subject>interneuron</subject><subject>Interneurons - cytology</subject><subject>Interneurons - physiology</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>morphology</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Prosencephalon - cytology</subject><subject>Prosencephalon - embryology</subject><subject>Prosencephalon - physiology</subject><subject>Robo</subject><subject>Signal Transduction - physiology</subject><issn>1047-3211</issn><issn>1460-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtLAzEUhYMoPqpLtzIrcTOaxyRpFgpSHxWLQqkgbkImc2NHp5OaTIv-e6e0WN24uuGej3NPOAgdEnxKsGJnFoL14SwfT3FGNtAuyQROKVFqs33jTKaMErKD9mJ8w5hIyuk22iGKCdEVahedj8aQDH0FiXftzD1Lyjpp2uUVzKHy0wnUzULr-dCU1lTJXd1AqGEWfB330ZYzVYSD1eygp5vrUa-fDh5v73qXg9RySpuUyTyTDlTGhTDQBY4dJUVune0WXZPLHGPgnEonHKbUCUFYlhFSGCUIF0XBOuhi6Tud5RMobJspmEpPQzkx4Ut7U-q_Sl2O9aufayoU40y2Bscrg-A_ZhAbPSmjhaoyNfhZ1EIy3h5VLXjyL0gyRQWjC7qD0iVqg48xgPvJQ7BedKOX3ehlNy1_9PsTa3pVxtqwjA18_ugmvC_ySa77zy962O_fD0YY6wf2Daktm4Y</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Barber, Melissa</creator><creator>Di Meglio, Thomas</creator><creator>Andrews, William D.</creator><creator>Hernández-Miranda, Luis R.</creator><creator>Murakami, Fujio</creator><creator>Chédotal, Alain</creator><creator>Parnavelas, John G.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090701</creationdate><title>The Role of Robo3 in the Development of Cortical Interneurons</title><author>Barber, Melissa ; Di Meglio, Thomas ; Andrews, William D. ; Hernández-Miranda, Luis R. ; Murakami, Fujio ; Chédotal, Alain ; Parnavelas, John G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-37b47fe94566ae8e50f21dbcfc8d8ab7b00e5527f6f022f66134411da96156dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Cell Differentiation</topic><topic>Cerebral Cortex - cytology</topic><topic>Cerebral Cortex - embryology</topic><topic>Cerebral Cortex - pathology</topic><topic>interneuron</topic><topic>Interneurons - cytology</topic><topic>Interneurons - physiology</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>morphology</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Prosencephalon - cytology</topic><topic>Prosencephalon - embryology</topic><topic>Prosencephalon - physiology</topic><topic>Robo</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barber, Melissa</creatorcontrib><creatorcontrib>Di Meglio, Thomas</creatorcontrib><creatorcontrib>Andrews, William D.</creatorcontrib><creatorcontrib>Hernández-Miranda, Luis R.</creatorcontrib><creatorcontrib>Murakami, Fujio</creatorcontrib><creatorcontrib>Chédotal, Alain</creatorcontrib><creatorcontrib>Parnavelas, John G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barber, Melissa</au><au>Di Meglio, Thomas</au><au>Andrews, William D.</au><au>Hernández-Miranda, Luis R.</au><au>Murakami, Fujio</au><au>Chédotal, Alain</au><au>Parnavelas, John G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Robo3 in the Development of Cortical Interneurons</atitle><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle><addtitle>Cereb Cortex</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>19</volume><issue>suppl-1</issue><spage>i22</spage><epage>i31</epage><pages>i22-i31</pages><issn>1047-3211</issn><eissn>1460-2199</eissn><abstract>A number of studies in recent years have shown that members of the Roundabout (Robo) receptor family, Robo1 and Robo2, play significant roles in the formation of axonal tracks in the developing forebrain and in the migration and morphological differentiation of cortical interneurons. Here, we investigated the expression and function of Robo3 in the developing cortex. We found that this receptor is strongly expressed in the preplate layer and cortical hem of the early cortex where it colocalizes with markers of Cajal–Retzius cells and interneurons. Analysis of Robo3 mutant mice at early (embryonic day [E] 13.5) and late (E18.5) stages of corticogenesis revealed no significant change in the number of interneurons, but a change in their morphology at E13.5. However, preliminary analysis on a small number of mice that lacked all 3 Robo receptors indicated a marked reduction in the number of cortical interneurons, but only a limited effect on their morphology. These observations and the results of other recent studies suggest a complex interplay between the 3 Robo receptors in regulating the number, migration and morphological differentiation of cortical interneurons.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>19366869</pmid><doi>10.1093/cercor/bhp041</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1047-3211 |
| ispartof | Cerebral cortex (New York, N.Y. 1991), 2009-07, Vol.19 (suppl-1), p.i22-i31 |
| issn | 1047-3211 1460-2199 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2693537 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Cell Differentiation Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - pathology interneuron Interneurons - cytology Interneurons - physiology Membrane Proteins - metabolism Mice morphology Nerve Tissue Proteins - metabolism Prosencephalon - cytology Prosencephalon - embryology Prosencephalon - physiology Robo Signal Transduction - physiology |
| title | The Role of Robo3 in the Development of Cortical Interneurons |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T20%3A42%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Role%20of%20Robo3%20in%20the%20Development%20of%20Cortical%20Interneurons&rft.jtitle=Cerebral%20cortex%20(New%20York,%20N.Y.%201991)&rft.au=Barber,%20Melissa&rft.date=2009-07-01&rft.volume=19&rft.issue=suppl-1&rft.spage=i22&rft.epage=i31&rft.pages=i22-i31&rft.issn=1047-3211&rft.eissn=1460-2199&rft_id=info:doi/10.1093/cercor/bhp041&rft_dat=%3Cproquest_pubme%3E67351349%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1492632351&rft_id=info:pmid/19366869&rfr_iscdi=true |