Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

Interleukin-10 is known to dampen immune responses and contribute to the persistence of chronic viruses and parasites. Thomas Braciale and his colleagues show in mice that the anti-inflammatory cytokine is produced, along with proinflammatory cytokines, by effector CD4 + and CD8 + T cells during an...

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Veröffentlicht in:	Nature medicine 2009-03, Vol.15 (3), p.277-284
Hauptverfasser:	Madan, Rajat, Braciale, Thomas J, Karp, Christopher L, Sun, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Biomedical and Life Sciences Biomedicine Bronchoalveolar Lavage Fluid Cancer Research CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell Line Cellular biology Cellular control mechanisms Complications and side effects Cytokines Development and progression Dogs Flow Cytometry Genetic aspects Health aspects Immune response Immunological research Immunology Infectious Diseases Inflammation Influenza Influenza virus Interleukin-10 Interleukin-10 - biosynthesis Lymphocyte Depletion Metabolic Diseases Mice Mice, Inbred BALB C Molecular biology Molecular Medicine Neurosciences Orthomyxoviridae Infections - immunology Physiological aspects Pneumonia - immunology Pneumonia - prevention & control Regulation Reverse Transcriptase Polymerase Chain Reaction Risk factors T cells
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