Two Tuberculosis Genotyping Clusters, One Preventable Outbreak
In 2006, eight community tuberculosis (TB) cases and a ninth incarceration-related case were identified during an outbreak investigation, which included genotyping of all Mycobacterium tuberculosis isolates. In 1996, the source patient had pulmonary TB but completed only two weeks of treatment. From...
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| Veröffentlicht in: | Public health reports (1974) 2009-07, Vol.124 (4), p.490-494 |
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| container_end_page | 494 |
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| container_issue | 4 |
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| container_title | Public health reports (1974) |
| container_volume | 124 |
| creator | Buff, Ann M. Sosa, Lynn E. Hoopes, Andrea J. Buxton-Morris, Deborah Condren, Thomas B. Hadler, James L. Haddad, Maryam B. Moonan, Patrick K. Lobato, Mark N. |
| description | In 2006, eight community tuberculosis (TB) cases and a ninth incarceration-related case were identified during an outbreak investigation, which included genotyping of all Mycobacterium tuberculosis isolates. In 1996, the source patient had pulmonary TB but completed only two weeks of treatment. From February 2005 to May 2006, the source patient lived in four different locations while contagious. The outbreak cases had matching isolate spoligotypes; however, the mycobacterial interspersed repetitive unit (MIRU) patterns from isolates from two secondary cases differed by one tandem repeat at a single MIRU locus. The source patient's isolates showed a mixed mycobacterial population with both MIRU patterns. Traditional and molecular epidemiologic methods linked eight secondary TB cases to a single source patient whose incomplete initial treatment, incarceration, delayed diagnosis, and housing instability resulted in extensive transmission. Adequate treatment of the source patient's initial TB or early diagnosis of recurrent TB could have prevented this outbreak. |
| doi_str_mv | 10.1177/003335490912400405 |
| format | Article |
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In 1996, the source patient had pulmonary TB but completed only two weeks of treatment. From February 2005 to May 2006, the source patient lived in four different locations while contagious. The outbreak cases had matching isolate spoligotypes; however, the mycobacterial interspersed repetitive unit (MIRU) patterns from isolates from two secondary cases differed by one tandem repeat at a single MIRU locus. The source patient's isolates showed a mixed mycobacterial population with both MIRU patterns. Traditional and molecular epidemiologic methods linked eight secondary TB cases to a single source patient whose incomplete initial treatment, incarceration, delayed diagnosis, and housing instability resulted in extensive transmission. Adequate treatment of the source patient's initial TB or early diagnosis of recurrent TB could have prevented this outbreak.</description><identifier>ISSN: 0033-3549</identifier><identifier>EISSN: 1468-2877</identifier><identifier>DOI: 10.1177/003335490912400405</identifier><identifier>PMID: 19618785</identifier><identifier>CODEN: PHRPA6</identifier><language>eng</language><publisher>Los Angeles, CA: Association of Schools of Public Health</publisher><subject>Adult ; Adults ; Bacterial diseases ; Biological and medical sciences ; Cluster Analysis ; Connecticut - epidemiology ; Criminal punishment ; Disease outbreaks ; Disease Outbreaks - prevention & control ; Disease transmission ; Epidemics ; Epidemiology ; Female ; Genotype ; Genotype & phenotype ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Latent tuberculosis ; Male ; Medical Audit ; Medical sciences ; Medical treatment ; Miscellaneous ; Mycobacterium ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - genetics ; Patients ; PRACTICE ; Prevention and actions ; Preventive medicine ; Public health ; Public health. 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Hygiene-occupational medicine ; Pulmonary tuberculosis ; Tuberculosis ; Tuberculosis - diagnosis ; Tuberculosis - epidemiology ; Tuberculosis - genetics ; Tuberculosis - prevention & control ; Tuberculosis - transmission ; Tuberculosis and atypical mycobacterial infections ; Young Adult</subject><ispartof>Public health reports (1974), 2009-07, Vol.124 (4), p.490-494</ispartof><rights>Copyright © 2009 Association of Schools of Public Health</rights><rights>2009 US Surgeon General's Office</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Jul/Aug 2009</rights><rights>2009 Association of Schools of Public Health 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-56a7dda47a817af87f86c188a9da01c2ee13d8dab34999c0df2702a28b197a713</citedby><cites>FETCH-LOGICAL-c519t-56a7dda47a817af87f86c188a9da01c2ee13d8dab34999c0df2702a28b197a713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25682263$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25682263$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,21819,27866,27924,27925,43621,43622,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22393800$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19618785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buff, Ann M.</creatorcontrib><creatorcontrib>Sosa, Lynn E.</creatorcontrib><creatorcontrib>Hoopes, Andrea J.</creatorcontrib><creatorcontrib>Buxton-Morris, Deborah</creatorcontrib><creatorcontrib>Condren, Thomas B.</creatorcontrib><creatorcontrib>Hadler, James L.</creatorcontrib><creatorcontrib>Haddad, Maryam B.</creatorcontrib><creatorcontrib>Moonan, Patrick K.</creatorcontrib><creatorcontrib>Lobato, Mark N.</creatorcontrib><title>Two Tuberculosis Genotyping Clusters, One Preventable Outbreak</title><title>Public health reports (1974)</title><addtitle>Public Health Rep</addtitle><description>In 2006, eight community tuberculosis (TB) cases and a ninth incarceration-related case were identified during an outbreak investigation, which included genotyping of all Mycobacterium tuberculosis isolates. In 1996, the source patient had pulmonary TB but completed only two weeks of treatment. From February 2005 to May 2006, the source patient lived in four different locations while contagious. The outbreak cases had matching isolate spoligotypes; however, the mycobacterial interspersed repetitive unit (MIRU) patterns from isolates from two secondary cases differed by one tandem repeat at a single MIRU locus. The source patient's isolates showed a mixed mycobacterial population with both MIRU patterns. Traditional and molecular epidemiologic methods linked eight secondary TB cases to a single source patient whose incomplete initial treatment, incarceration, delayed diagnosis, and housing instability resulted in extensive transmission. Adequate treatment of the source patient's initial TB or early diagnosis of recurrent TB could have prevented this outbreak.</description><subject>Adult</subject><subject>Adults</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Cluster Analysis</subject><subject>Connecticut - epidemiology</subject><subject>Criminal punishment</subject><subject>Disease outbreaks</subject><subject>Disease Outbreaks - prevention & control</subject><subject>Disease transmission</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Latent tuberculosis</subject><subject>Male</subject><subject>Medical Audit</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Miscellaneous</subject><subject>Mycobacterium</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Patients</subject><subject>PRACTICE</subject><subject>Prevention and actions</subject><subject>Preventive medicine</subject><subject>Public health</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Pulmonary tuberculosis</subject><subject>Tuberculosis</subject><subject>Tuberculosis - diagnosis</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - genetics</subject><subject>Tuberculosis - prevention & control</subject><subject>Tuberculosis - transmission</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Young Adult</subject><issn>0033-3549</issn><issn>1468-2877</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7TQ</sourceid><recordid>eNp9kUtvEzEUhS0EoiHwB5BAIyRYdagf49emEoqgRaqULsLauuO5EyZMxsGeKeq_x1GihodUb7zwd47vuYeQ14x-ZEzrC0qFELKy1DJeUVpR-YTMWKVMyY3WT8lsD5R74oy8SGlD8-FMPCdnzCpmtJEzcrn6FYrVVGP0Ux9Sl4orHMJ4v-uGdbHopzRiTOfFcsDiNuIdDiPUPRbLaawjwo-X5FkLfcJXx3tOvn35vFpclzfLq6-LTzell8yOpVSgmwYqDYZpaI1ujfLMGLANUOY5IhONaaAWlbXW06blmnLgpmZWg2ZiTi4Pvrup3mLj8xwRereL3RbivQvQub9fhu67W4c7x5UVTPFs8OFoEMPPCdPotl3y2PcwYJiSU1pSZbjJ4Lt_wE2Y4pDDOSPziqVUOkP8APkYUorYPkzCqNt34_7vJove_pnhJDmWkYH3RwCSh76NMPguPXCcCytMNp6TiwOXYI2n8R79-s1BsUljiCdHmSNzJcRvLe-tXg</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Buff, Ann M.</creator><creator>Sosa, Lynn E.</creator><creator>Hoopes, Andrea J.</creator><creator>Buxton-Morris, Deborah</creator><creator>Condren, Thomas B.</creator><creator>Hadler, James L.</creator><creator>Haddad, Maryam B.</creator><creator>Moonan, Patrick K.</creator><creator>Lobato, Mark N.</creator><general>Association of Schools of Public Health</general><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TQ</scope><scope>ASE</scope><scope>DHY</scope><scope>DON</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090701</creationdate><title>Two Tuberculosis Genotyping Clusters, One Preventable Outbreak</title><author>Buff, Ann M. ; Sosa, Lynn E. ; Hoopes, Andrea J. ; Buxton-Morris, Deborah ; Condren, Thomas B. ; Hadler, James L. ; Haddad, Maryam B. ; Moonan, Patrick K. ; Lobato, Mark N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-56a7dda47a817af87f86c188a9da01c2ee13d8dab34999c0df2702a28b197a713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Cluster Analysis</topic><topic>Connecticut - epidemiology</topic><topic>Criminal punishment</topic><topic>Disease outbreaks</topic><topic>Disease Outbreaks - prevention & control</topic><topic>Disease transmission</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Latent tuberculosis</topic><topic>Male</topic><topic>Medical Audit</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Miscellaneous</topic><topic>Mycobacterium</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Patients</topic><topic>PRACTICE</topic><topic>Prevention and actions</topic><topic>Preventive medicine</topic><topic>Public health</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Pulmonary tuberculosis</topic><topic>Tuberculosis</topic><topic>Tuberculosis - diagnosis</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis - genetics</topic><topic>Tuberculosis - prevention & control</topic><topic>Tuberculosis - transmission</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buff, Ann M.</creatorcontrib><creatorcontrib>Sosa, Lynn E.</creatorcontrib><creatorcontrib>Hoopes, Andrea J.</creatorcontrib><creatorcontrib>Buxton-Morris, Deborah</creatorcontrib><creatorcontrib>Condren, Thomas B.</creatorcontrib><creatorcontrib>Hadler, James L.</creatorcontrib><creatorcontrib>Haddad, Maryam B.</creatorcontrib><creatorcontrib>Moonan, Patrick K.</creatorcontrib><creatorcontrib>Lobato, Mark N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PAIS Index</collection><collection>British Nursing Index</collection><collection>PAIS International</collection><collection>PAIS International (Ovid)</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Public health reports (1974)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buff, Ann M.</au><au>Sosa, Lynn E.</au><au>Hoopes, Andrea J.</au><au>Buxton-Morris, Deborah</au><au>Condren, Thomas B.</au><au>Hadler, James L.</au><au>Haddad, Maryam B.</au><au>Moonan, Patrick K.</au><au>Lobato, Mark N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two Tuberculosis Genotyping Clusters, One Preventable Outbreak</atitle><jtitle>Public health reports (1974)</jtitle><addtitle>Public Health Rep</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>124</volume><issue>4</issue><spage>490</spage><epage>494</epage><pages>490-494</pages><issn>0033-3549</issn><eissn>1468-2877</eissn><coden>PHRPA6</coden><abstract>In 2006, eight community tuberculosis (TB) cases and a ninth incarceration-related case were identified during an outbreak investigation, which included genotyping of all Mycobacterium tuberculosis isolates. In 1996, the source patient had pulmonary TB but completed only two weeks of treatment. From February 2005 to May 2006, the source patient lived in four different locations while contagious. The outbreak cases had matching isolate spoligotypes; however, the mycobacterial interspersed repetitive unit (MIRU) patterns from isolates from two secondary cases differed by one tandem repeat at a single MIRU locus. The source patient's isolates showed a mixed mycobacterial population with both MIRU patterns. Traditional and molecular epidemiologic methods linked eight secondary TB cases to a single source patient whose incomplete initial treatment, incarceration, delayed diagnosis, and housing instability resulted in extensive transmission. Adequate treatment of the source patient's initial TB or early diagnosis of recurrent TB could have prevented this outbreak.</abstract><cop>Los Angeles, CA</cop><pub>Association of Schools of Public Health</pub><pmid>19618785</pmid><doi>10.1177/003335490912400405</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Access via SAGE; MEDLINE; PAIS Index; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Adults Bacterial diseases Biological and medical sciences Cluster Analysis Connecticut - epidemiology Criminal punishment Disease outbreaks Disease Outbreaks - prevention & control Disease transmission Epidemics Epidemiology Female Genotype Genotype & phenotype Human bacterial diseases Humans Infant Infectious diseases Latent tuberculosis Male Medical Audit Medical sciences Medical treatment Miscellaneous Mycobacterium Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Patients PRACTICE Prevention and actions Preventive medicine Public health Public health. Hygiene Public health. Hygiene-occupational medicine Pulmonary tuberculosis Tuberculosis Tuberculosis - diagnosis Tuberculosis - epidemiology Tuberculosis - genetics Tuberculosis - prevention & control Tuberculosis - transmission Tuberculosis and atypical mycobacterial infections Young Adult |
| title | Two Tuberculosis Genotyping Clusters, One Preventable Outbreak |
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