Bicarbonate contributes to GABAA receptor-mediated neuronal excitation in surgically resected human hypothalamic hamartomas

Summary The role of bicarbonate (HCO3− ) in GABAA receptor-mediated depolarization of human hypothalamic hamartoma (HH) neurons was investigated using cellular electrophysiological and calcium imaging techniques. Activation of GABAA receptors with muscimol (30 μM) provoked neuronal excitation in ove...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Epilepsy research 2009-01, Vol.83 (1), p.89-93
Hauptverfasser:	Kim, Do-Young, Fenoglio, Kristina A, Kerrigan, John F, Rho, Jong M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Bicarbonates - metabolism Biological and medical sciences Calcium - metabolism Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - physiology Child Child, Preschool Electrophysiology Female GABA Agonists - pharmacology GABA-A Receptor Agonists Gramicidin Hamartoma - complications Hamartoma - physiopathology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Hypothalamic Neoplasms - complications Hypothalamic Neoplasms - physiopathology Infant Male Medical sciences Muscimol - pharmacology Nervous system (semeiology, syndromes) Neurology Neurons - physiology Neuropharmacology Neuroprotective agent Patch-Clamp Techniques Pharmacology. Drug treatments Receptors, GABA-A - physiology Seizures - etiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!