Antiretroviral Therapy Adherence and Viral Suppression in HIV-Infected Drug Users: Comparison of Self-Report and Electronic Monitoring
To compare electronically monitored (MEMS) with self-reported adherence in drug users, including the impact of adherence on HIV load, we conducted a 6-month observational study of 67 antiretroviral-experienced current and former drug users. Adherence (percentage of doses taken as prescribed) was cal...
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| Veröffentlicht in: | Clinical infectious diseases 2001-10, Vol.33 (8), p.1417-1423 |
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| creator | Arnsten, Julia H. Demas, Penelope A. Farzadegan, Homayoon Grant, Richard W. Gourevitch, Marc N. Chang, Chee-Jen Buono, Donna Eckholdt, Haftan Howard, Andrea A. Schoenbaum, Ellie E. |
| description | To compare electronically monitored (MEMS) with self-reported adherence in drug users, including the impact of adherence on HIV load, we conducted a 6-month observational study of 67 antiretroviral-experienced current and former drug users. Adherence (percentage of doses taken as prescribed) was calculated for both the day and the week preceding each of 6 research visits. Mean self-reported 1-day adherence was 79% (median, 86%), and mean self-reported 1-week adherence was 78% (median, 85%). Mean MEMS 1-day adherence was 57% (median, 52%), and mean MEMS 1-week adherence was 53% (median, 49%). One-day and 1-week estimates were highly correlated (r > .8 for both measures). Both self-reported and MEMS adherence were correlated with concurrent HIV load (r = .43–.60), but the likelihood of achieving virologic suppression was greater if MEMS adherence was high than if self-reported adherence was high. We conclude that self-reported adherence is higher than MEMS adherence, but a strong relationship exists between both measures and virus load. However, electronic monitoring is more sensitive than self-report for the detection of nonadherence and should be used in adherence intervention studies. |
| doi_str_mv | 10.1086/323201 |
| format | Article |
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Adherence (percentage of doses taken as prescribed) was calculated for both the day and the week preceding each of 6 research visits. Mean self-reported 1-day adherence was 79% (median, 86%), and mean self-reported 1-week adherence was 78% (median, 85%). Mean MEMS 1-day adherence was 57% (median, 52%), and mean MEMS 1-week adherence was 53% (median, 49%). One-day and 1-week estimates were highly correlated (r > .8 for both measures). Both self-reported and MEMS adherence were correlated with concurrent HIV load (r = .43–.60), but the likelihood of achieving virologic suppression was greater if MEMS adherence was high than if self-reported adherence was high. We conclude that self-reported adherence is higher than MEMS adherence, but a strong relationship exists between both measures and virus load. However, electronic monitoring is more sensitive than self-report for the detection of nonadherence and should be used in adherence intervention studies.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/323201</identifier><identifier>PMID: 11550118</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; AIDS ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretroviral Therapy, Highly Active ; Antiretrovirals ; Antiviral agents ; Antivirals ; Biological and medical sciences ; Bottles ; Dosage ; Drug Monitoring ; Electronics ; Female ; HIV ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - virology ; HIV-1 - physiology ; HIV/AIDS ; Humans ; Male ; Medical sciences ; Medications ; Microelectromechanical systems ; Middle Aged ; Patient Compliance ; Pharmacology. Drug treatments ; Self Disclosure ; Substance-Related Disorders - complications ; Surveys and Questionnaires ; Viral Load ; Virology ; Viruses</subject><ispartof>Clinical infectious diseases, 2001-10, Vol.33 (8), p.1417-1423</ispartof><rights>Copyright 2001 The Infectious Diseases Society of America</rights><rights>2001 by the Infectious Diseases Society of America 2001</rights><rights>2002 INIST-CNRS</rights><rights>2001 by the Infectious Diseases Society of America. All rights reserved. 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-bb573b740c056785a9a078fec7644f5688e5817e57706fdf81db5afba174de5f3</citedby><cites>FETCH-LOGICAL-c508t-bb573b740c056785a9a078fec7644f5688e5817e57706fdf81db5afba174de5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4482793$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4482793$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14101221$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11550118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arnsten, Julia H.</creatorcontrib><creatorcontrib>Demas, Penelope A.</creatorcontrib><creatorcontrib>Farzadegan, Homayoon</creatorcontrib><creatorcontrib>Grant, Richard W.</creatorcontrib><creatorcontrib>Gourevitch, Marc N.</creatorcontrib><creatorcontrib>Chang, Chee-Jen</creatorcontrib><creatorcontrib>Buono, Donna</creatorcontrib><creatorcontrib>Eckholdt, Haftan</creatorcontrib><creatorcontrib>Howard, Andrea A.</creatorcontrib><creatorcontrib>Schoenbaum, Ellie E.</creatorcontrib><title>Antiretroviral Therapy Adherence and Viral Suppression in HIV-Infected Drug Users: Comparison of Self-Report and Electronic Monitoring</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>To compare electronically monitored (MEMS) with self-reported adherence in drug users, including the impact of adherence on HIV load, we conducted a 6-month observational study of 67 antiretroviral-experienced current and former drug users. 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However, electronic monitoring is more sensitive than self-report for the detection of nonadherence and should be used in adherence intervention studies.</description><subject>Adult</subject><subject>AIDS</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Antiretrovirals</subject><subject>Antiviral agents</subject><subject>Antivirals</subject><subject>Biological and medical sciences</subject><subject>Bottles</subject><subject>Dosage</subject><subject>Drug Monitoring</subject><subject>Electronics</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - physiology</subject><subject>HIV/AIDS</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medications</subject><subject>Microelectromechanical systems</subject><subject>Middle Aged</subject><subject>Patient Compliance</subject><subject>Pharmacology. Drug treatments</subject><subject>Self Disclosure</subject><subject>Substance-Related Disorders - complications</subject><subject>Surveys and Questionnaires</subject><subject>Viral Load</subject><subject>Virology</subject><subject>Viruses</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFuEzEQhlcIREuAJ0DIHOhtwV7ba4cDUpQWEqkIibQV4mJ5d8epy8Ze7N2qfQGeG6cbJXDgYs_o__zPeCbLXhL8jmBZvqcFLTB5lB0TTkVe8il5nGLMZc4klUfZsxhvMCZEYv40OyKE821ynP2eud4G6IO_tUG36OIagu7u0axJAbgakHYNunrQVkPXBYjReoesQ4vlVb50BuoeGnQahjW6jBDiBzT3m04HGxPmDVpBa_Jv0PnQP3idtelF8M7W6Es6ex-sWz_PnhjdRnixuyfZ5aezi_kiP__6eTmfnec1x7LPq4oLWgmGa8xLIbmeaixkakGUjBleSglcEgFcCFyaxkjSVFybShPBGuCGTrKPo283VBtoanB9-pnqgt3ocK-8tupfxdlrtfa3qiinRclIMjjZGQT_a4DYq42NNbStduCHqIhkfEopO4B18DEGMPsiBKvtytS4sgS-_rulA7bbUQLe7gAda92aoF1t44FjBJOi2Bq9GTk_dP8v9mpkbmIa_J5iTBYitT3J8lG2sYe7vazDT1UKKrhafP-RRlGsKCGlOqV_AEszwh4</recordid><startdate>20011015</startdate><enddate>20011015</enddate><creator>Arnsten, Julia H.</creator><creator>Demas, Penelope A.</creator><creator>Farzadegan, Homayoon</creator><creator>Grant, Richard W.</creator><creator>Gourevitch, Marc N.</creator><creator>Chang, Chee-Jen</creator><creator>Buono, Donna</creator><creator>Eckholdt, Haftan</creator><creator>Howard, Andrea A.</creator><creator>Schoenbaum, Ellie E.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20011015</creationdate><title>Antiretroviral Therapy Adherence and Viral Suppression in HIV-Infected Drug Users: Comparison of Self-Report and Electronic Monitoring</title><author>Arnsten, Julia H. ; Demas, Penelope A. ; Farzadegan, Homayoon ; Grant, Richard W. ; Gourevitch, Marc N. ; Chang, Chee-Jen ; Buono, Donna ; Eckholdt, Haftan ; Howard, Andrea A. ; Schoenbaum, Ellie E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-bb573b740c056785a9a078fec7644f5688e5817e57706fdf81db5afba174de5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>AIDS</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Antiretrovirals</topic><topic>Antiviral agents</topic><topic>Antivirals</topic><topic>Biological and medical sciences</topic><topic>Bottles</topic><topic>Dosage</topic><topic>Drug Monitoring</topic><topic>Electronics</topic><topic>Female</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - physiology</topic><topic>HIV/AIDS</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medications</topic><topic>Microelectromechanical systems</topic><topic>Middle Aged</topic><topic>Patient Compliance</topic><topic>Pharmacology. Drug treatments</topic><topic>Self Disclosure</topic><topic>Substance-Related Disorders - complications</topic><topic>Surveys and Questionnaires</topic><topic>Viral Load</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arnsten, Julia H.</creatorcontrib><creatorcontrib>Demas, Penelope A.</creatorcontrib><creatorcontrib>Farzadegan, Homayoon</creatorcontrib><creatorcontrib>Grant, Richard W.</creatorcontrib><creatorcontrib>Gourevitch, Marc N.</creatorcontrib><creatorcontrib>Chang, Chee-Jen</creatorcontrib><creatorcontrib>Buono, Donna</creatorcontrib><creatorcontrib>Eckholdt, Haftan</creatorcontrib><creatorcontrib>Howard, Andrea A.</creatorcontrib><creatorcontrib>Schoenbaum, Ellie E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arnsten, Julia H.</au><au>Demas, Penelope A.</au><au>Farzadegan, Homayoon</au><au>Grant, Richard W.</au><au>Gourevitch, Marc N.</au><au>Chang, Chee-Jen</au><au>Buono, Donna</au><au>Eckholdt, Haftan</au><au>Howard, Andrea A.</au><au>Schoenbaum, Ellie E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiretroviral Therapy Adherence and Viral Suppression in HIV-Infected Drug Users: Comparison of Self-Report and Electronic Monitoring</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2001-10-15</date><risdate>2001</risdate><volume>33</volume><issue>8</issue><spage>1417</spage><epage>1423</epage><pages>1417-1423</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>To compare electronically monitored (MEMS) with self-reported adherence in drug users, including the impact of adherence on HIV load, we conducted a 6-month observational study of 67 antiretroviral-experienced current and former drug users. Adherence (percentage of doses taken as prescribed) was calculated for both the day and the week preceding each of 6 research visits. Mean self-reported 1-day adherence was 79% (median, 86%), and mean self-reported 1-week adherence was 78% (median, 85%). Mean MEMS 1-day adherence was 57% (median, 52%), and mean MEMS 1-week adherence was 53% (median, 49%). One-day and 1-week estimates were highly correlated (r > .8 for both measures). Both self-reported and MEMS adherence were correlated with concurrent HIV load (r = .43–.60), but the likelihood of achieving virologic suppression was greater if MEMS adherence was high than if self-reported adherence was high. We conclude that self-reported adherence is higher than MEMS adherence, but a strong relationship exists between both measures and virus load. However, electronic monitoring is more sensitive than self-report for the detection of nonadherence and should be used in adherence intervention studies.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11550118</pmid><doi>10.1086/323201</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult AIDS Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active Antiretrovirals Antiviral agents Antivirals Biological and medical sciences Bottles Dosage Drug Monitoring Electronics Female HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - virology HIV-1 - physiology HIV/AIDS Humans Male Medical sciences Medications Microelectromechanical systems Middle Aged Patient Compliance Pharmacology. Drug treatments Self Disclosure Substance-Related Disorders - complications Surveys and Questionnaires Viral Load Virology Viruses |
| title | Antiretroviral Therapy Adherence and Viral Suppression in HIV-Infected Drug Users: Comparison of Self-Report and Electronic Monitoring |
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