Cochlear implants and ex vivo BDNF gene therapy protect spiral ganglion neurons

Spiral ganglion neurons often degenerate in the deaf ear, compromising the function of cochlear implants. Cochlear implant function can be improved by good preservation of the spiral ganglion neurons, which are the target of electrical stimulation by the implant. Brain derived neurotrophic factor (B...

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Veröffentlicht in:	Hearing research 2007-06, Vol.228 (1), p.180-187
Hauptverfasser:	Rejali, Darius, Lee, Valerie A., Abrashkin, Karen A., Humayun, Nousheen, Swiderski, Donald L., Raphael, Yehoash
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus vector Animals BDNF Biological and medical sciences Brain-Derived Neurotrophic Factor - biosynthesis Brain-Derived Neurotrophic Factor - genetics Cell Survival Cells, Cultured Cochlear Implantation Cochlear Implants Deafness - chemically induced Deafness - genetics Deafness - metabolism Deafness - pathology Deafness - surgery Deafness - therapy Disease Models, Animal Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ethacrynic Acid Ex vivo gene therapy Feasibility Studies Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Genetic Therapy - instrumentation Genetic Therapy - methods Genetic Vectors Guinea pig Guinea Pigs Kanamycin Medical sciences Nerve Degeneration - chemically induced Nerve Degeneration - genetics Nerve Degeneration - metabolism Nerve Degeneration - pathology Nerve Degeneration - prevention & control Nerve protection Neurons - metabolism Non tumoral diseases Otorhinolaryngology. Stomatology Prosthesis Design Sepharose - metabolism Spiral Ganglion - metabolism Spiral Ganglion - pathology Transduction, Genetic Vertebrates: nervous system and sense organs
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