inhibitor of interleukin-6 trans-signalling, sgp130, contributes to impaired acute phase response in human chronic liver disease

In chronic liver disease, high circulating interleukin (IL)-6 contrasts with a poor acute phase response. We evaluated the impact of liver and circulating IL-6-receptor (IL-6R) forms on IL-6 bioactivity in chronic liver disease. IL-6, soluble IL-6-receptor and sgp130 levels were assayed in plasma fr...

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Veröffentlicht in:	Clinical and experimental immunology 2009-06, Vol.156 (3), p.518-527
Hauptverfasser:	Lemmers, A, Gustot, T, Durnez, A, Evrard, S, Moreno, C, Quertinmont, E, Vercruysse, V, Demetter, P, Franchimont, D, Le Moine, O, Geerts, A, Devière, J
Format:	Artikel
Sprache:	eng
Schlagworte:	acute phase response Acute-Phase Reaction - immunology Adult Biomarkers - blood Cells, Cultured cirrhosis Cytokine Receptor gp130 - blood Cytokine Receptor gp130 - genetics Disease Progression Female Gene Expression Regulation - immunology hepatic stellate cell Hepatitis C virus Hepatitis C, Chronic - immunology Hepatocytes - immunology Humans Hypertension, Portal - immunology interleukin-6 Interleukin-6 - blood Liver Diseases, Alcoholic - immunology Male Middle Aged Receptors, Interleukin-6 - blood Receptors, Interleukin-6 - genetics RNA, Messenger - genetics sgp130 Translational Studies Tumor Cells, Cultured
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