Acute-phase responsiveness of mannose-binding lectin in community-acquired pneumonia is highly dependent upon MBL2 genotypes

Mannose-binding lectin (MBL) is a pattern recognition receptor of the complement system and plays an important role in innate immunity. Whether or not MBL acts as an acute-phase response protein in infection has been an issue of extensive debate, because MBL responses have shown a high degree of het...

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Veröffentlicht in:	Clinical and experimental immunology 2009-06, Vol.156 (3), p.488-494
Hauptverfasser:	Herpers, B.L, Endeman, H, de Jong, B.A.W, de Jongh, B.M, Grutters, J.C, Biesma, D.H, van Velzen-Blad, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute-Phase Reaction - genetics Acute-Phase Reaction - immunology Adult Aged Aged, 80 and over Analytical, structural and metabolic biochemistry Biological and medical sciences C-Reactive Protein - metabolism Community-Acquired Infections - genetics Community-Acquired Infections - immunology complement Female Fundamental and applied biological sciences. Psychology Genotype human studies Humans immunogenetics Male mannose-binding lectin Mannose-Binding Lectin - blood Mannose-Binding Lectin - genetics Mannose-Binding Lectin - immunology Middle Aged pneumonia Pneumonia - genetics Pneumonia - immunology Prospective Studies Translational Studies
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