Alternative Splicing of Drosophila Dscam Generates Axon Guidance Receptors that Exhibit Isoform-Specific Homophilic Binding

Dscam is an immunoglobulin (Ig) superfamily protein required for the formation of neuronal connections in Drosophila. Through alternative splicing, Dscam potentially gives rise to 19,008 different extracellular domains linked to one of two alternative transmembrane segments, resulting in 38,016 isof...

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Veröffentlicht in:	Cell 2004-09, Vol.118 (5), p.619-633
Hauptverfasser:	Wojtowicz, Woj M., Flanagan, John J., Millard, S.Sean, Zipursky, S.Lawrence, Clemens, James C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Amino Acid Sequence - genetics Animals Binding Sites - genetics Cell Adhesion Molecules Cell Communication - genetics Cell Differentiation - genetics Cell Membrane - genetics Cell Membrane - metabolism COS Cells Drosophila Drosophila melanogaster Drosophila Proteins Embryo, Nonmammalian - cytology Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Gene Expression Regulation, Developmental - genetics Growth Cones - metabolism Growth Cones - ultrastructure Nervous System - cytology Nervous System - embryology Nervous System - metabolism Protein Binding - genetics Protein Biosynthesis Protein Isoforms - biosynthesis Protein Isoforms - genetics Protein Isoforms - metabolism Protein Structure, Tertiary - genetics Proteins - genetics Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism
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