Repression of E-cadherin by the polycomb group protein EZH2 in cancer

Enhancer of zeste homolog 2 (EZH2) is a critical component of the polycomb-repressive complex 2 (PRC2), which is involved in gene silencing and histone H3 lysine 27 methylation. EZH2 has a master regulatory function in controlling such processes as stem cell differentiation, cell proliferation, earl...

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Veröffentlicht in:	Oncogene 2008-12, Vol.27 (58), p.7274-7284
Hauptverfasser:	Cao, Q, Yu, J, Dhanasekaran, S M, Kim, J H, Mani, R-S, Tomlins, S A, Mehra, R, Laxman, B, Cao, X, Kleer, C G, Varambally, S, Chinnaiyan, A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Benign Biological and medical sciences Breast Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cadherins - antagonists & inhibitors Cadherins - genetics Cancer Carcinogenesis Cell Biology Cell differentiation Cell Line, Transformed Cell Line, Tumor Cell physiology Cell proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Differentiation DNA Methylation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E-Cadherin Embryogenesis Enhancer of Zeste Homolog 2 Protein Enhancers Epithelial cells Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Gene Silencing Genetic aspects Genetics Health aspects Histone deacetylase Histone H3 Histones - metabolism Human Genetics Humans Inhibitor drugs Internal Medicine Internet Lysine Male Medicine Medicine & Public Health Methylation Molecular and cellular biology Neoplasm Invasiveness Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncogenes Oncology original-article Polycomb group proteins Polycomb Repressive Complex 2 Prostate Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proteins Repressor Proteins - genetics Repressor Proteins - metabolism Solid tumors Stem cells Transcription Factors - genetics Transcription Factors - metabolism Tumor suppressor genes Tumors Urinary bladder X-chromosome inactivation
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