TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans

Triggering receptor expressed on myeloid cells-like (TREM-like) transcript-1 (TLT-1), a type 1 single Ig domain orphan receptor specific to platelet and megakaryocyte alpha-granules, relocates to the platelet surface upon platelet stimulation. We found here that patients diagnosed with sepsis, in co...

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Veröffentlicht in:	The Journal of clinical investigation 2009-06, Vol.119 (6), p.1489-1501
Hauptverfasser:	Washington, A Valance, Gibot, Sébastien, Acevedo, Ismael, Gattis, James, Quigley, Laura, Feltz, Robert, De La Mota, Alina, Schubert, Rebecca L, Gomez-Rodriguez, Julio, Cheng, Jun, Dutra, Amalia, Pak, Evgenia, Chertov, Oleg, Rivera, Linette, Morales, Jessica, Lubkowski, Jacek, Hunter, Robert, Schwartzberg, Pamela L, McVicar, Daniel W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical research Blood platelets Fibrinogen - metabolism Genes Genetic aspects Hemorrhage Hemorrhage - complications Hemorrhage - genetics Hemorrhage - metabolism Humans Inflammation Inflammation - complications Inflammation - genetics Inflammation - metabolism Lipopolysaccharides - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Physiological aspects Plasma Platelet Aggregation - drug effects Prevention Protein Binding Receptors, Immunologic - blood Receptors, Immunologic - deficiency Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Risk factors Sepsis Sepsis - blood Solubility Thrombosis
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