tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

Tyrosine phosphorylation plays a critical role in regulating cellular function and is a central feature in signaling cascades involved in oncogenesis. The regulation of tyrosine phosphorylation is coordinately controlled by kinases and phosphatases (PTPs). Whereas activation of tyrosine kinases has...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-06, Vol.106 (23), p.9435-9440
Hauptverfasser:	Veeriah, Selvaraju, Brennan, Cameron, Meng, Shasha, Singh, Bhuvanesh, Fagin, James A, Solit, David B, Paty, Philip B, Rohle, Dan, Vivanco, Igor, Chmielecki, Juliann, Pao, William, Ladanyi, Marc, Gerald, William L, Liau, Linda, Cloughesy, Timothy C, Mischel, Paul S, Sander, Chris, Taylor, Barry, Schultz, Nikolaus, Major, John, Heguy, Adriana, Fang, Fang, Mellinghoff, Ingo K, Chan, Timothy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Biochemistry Biological Sciences Cancer Cell growth Chromosomes DNA Methylation Epigenetics Gene Deletion Gene Expression Regulation, Neoplastic Genes Genetic mutation Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioma Humans Kinases Methylation Mutation Neoplasms - genetics Neoplasms - metabolism Oncology Phosphorylation Proteins Receptor-Like Protein Tyrosine Phosphatases, Class 2 - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 2 - metabolism STAT3 Transcription Factor - metabolism Tumors
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