R2 magnetic resonance imaging of the liver in patients with iron overload
R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Forty-three patients (sickle cell anemia, n = 32; β-thalassemia major,...
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| Veröffentlicht in: | Blood 2009-05, Vol.113 (20), p.4853-4855 |
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| creator | Hankins, Jane S. McCarville, M. Beth Loeffler, Ralf B. Smeltzer, Matthew P. Onciu, Mihaela Hoffer, Fredric A. Li, Chin-Shang Wang, Winfred C. Ware, Russell E. Hillenbrand, Claudia M. |
| description | R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Forty-three patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038. |
| doi_str_mv | 10.1182/blood-2008-12-191643 |
| format | Article |
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Beth ; Loeffler, Ralf B. ; Smeltzer, Matthew P. ; Onciu, Mihaela ; Hoffer, Fredric A. ; Li, Chin-Shang ; Wang, Winfred C. ; Ware, Russell E. ; Hillenbrand, Claudia M.</creator><creatorcontrib>Hankins, Jane S. ; McCarville, M. Beth ; Loeffler, Ralf B. ; Smeltzer, Matthew P. ; Onciu, Mihaela ; Hoffer, Fredric A. ; Li, Chin-Shang ; Wang, Winfred C. ; Ware, Russell E. ; Hillenbrand, Claudia M.</creatorcontrib><description>R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Forty-three patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. 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Beth</creatorcontrib><creatorcontrib>Loeffler, Ralf B.</creatorcontrib><creatorcontrib>Smeltzer, Matthew P.</creatorcontrib><creatorcontrib>Onciu, Mihaela</creatorcontrib><creatorcontrib>Hoffer, Fredric A.</creatorcontrib><creatorcontrib>Li, Chin-Shang</creatorcontrib><creatorcontrib>Wang, Winfred C.</creatorcontrib><creatorcontrib>Ware, Russell E.</creatorcontrib><creatorcontrib>Hillenbrand, Claudia M.</creatorcontrib><title>R2 magnetic resonance imaging of the liver in patients with iron overload</title><title>Blood</title><addtitle>Blood</addtitle><description>R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Forty-three patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Calibration</subject><subject>Child</subject><subject>Clinical Trials and Observations</subject><subject>Female</subject><subject>Ferritins - analysis</subject><subject>Ferritins - blood</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Iron Overload - diagnostic imaging</subject><subject>Iron Overload - pathology</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - pathology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Imaging - standards</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metals (hemochromatosis...)</subject><subject>Other metabolic disorders</subject><subject>Radiography</subject><subject>Single-Blind Method</subject><subject>Young Adult</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU2LFDEQDaK44-o_EMlFb62p6iQ9uQiy-LGwIIieQzqpnon0JGPSM-K_N-sMu3rxVFD16tWr9xh7DuI1wBrfjHPOoUMh1h1gBwa07B-wFShcd0KgeMhWQgjdSTPABXtS63chQPaoHrMLMKilHoYVu_6CfOc2iZboeaGak0ueeGy9mDY8T3zZEp_jkQqPie_dEiktlf-My5bHkhPPbTRnF56yR5ObKz0710v27cP7r1efupvPH6-v3t10XhpYugnQODk6JUOYRkTlA3qYUCnfWuhGEQYy2qFRSig_SUfGDCoEOY6gBPaX7O2Jd38YdxR8k1PcbPelaS6_bHbR_jtJcWs3-WhRrzX0uhG8OhOU_ONAdbG7WD3Ns0uUD9XqAXuNemhAeQL6kmstNN0dAWFvM7B_MrC3GVhAe8qgrb34W-D90tn0Bnh5Brjq3TyVZnmsdzhsb0I_wP2n1Ow8Riq2-ua-pxAL-cWGHP-v5Deb56bF</recordid><startdate>20090514</startdate><enddate>20090514</enddate><creator>Hankins, Jane S.</creator><creator>McCarville, M. Beth</creator><creator>Loeffler, Ralf B.</creator><creator>Smeltzer, Matthew P.</creator><creator>Onciu, Mihaela</creator><creator>Hoffer, Fredric A.</creator><creator>Li, Chin-Shang</creator><creator>Wang, Winfred C.</creator><creator>Ware, Russell E.</creator><creator>Hillenbrand, Claudia M.</creator><general>Elsevier Inc</general><general>Americain Society of Hematology</general><general>American Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090514</creationdate><title>R2 magnetic resonance imaging of the liver in patients with iron overload</title><author>Hankins, Jane S. ; McCarville, M. Beth ; Loeffler, Ralf B. ; Smeltzer, Matthew P. ; Onciu, Mihaela ; Hoffer, Fredric A. ; Li, Chin-Shang ; Wang, Winfred C. ; Ware, Russell E. ; Hillenbrand, Claudia M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-f129a4ba54ddfb225cd2c1f255c54d2ab0d7e96a295505cf4ae9975dd4bb15023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Calibration</topic><topic>Child</topic><topic>Clinical Trials and Observations</topic><topic>Female</topic><topic>Ferritins - analysis</topic><topic>Ferritins - blood</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Iron Overload - diagnostic imaging</topic><topic>Iron Overload - pathology</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - pathology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Imaging - standards</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metals (hemochromatosis...)</topic><topic>Other metabolic disorders</topic><topic>Radiography</topic><topic>Single-Blind Method</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hankins, Jane S.</creatorcontrib><creatorcontrib>McCarville, M. Beth</creatorcontrib><creatorcontrib>Loeffler, Ralf B.</creatorcontrib><creatorcontrib>Smeltzer, Matthew P.</creatorcontrib><creatorcontrib>Onciu, Mihaela</creatorcontrib><creatorcontrib>Hoffer, Fredric A.</creatorcontrib><creatorcontrib>Li, Chin-Shang</creatorcontrib><creatorcontrib>Wang, Winfred C.</creatorcontrib><creatorcontrib>Ware, Russell E.</creatorcontrib><creatorcontrib>Hillenbrand, Claudia M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hankins, Jane S.</au><au>McCarville, M. Beth</au><au>Loeffler, Ralf B.</au><au>Smeltzer, Matthew P.</au><au>Onciu, Mihaela</au><au>Hoffer, Fredric A.</au><au>Li, Chin-Shang</au><au>Wang, Winfred C.</au><au>Ware, Russell E.</au><au>Hillenbrand, Claudia M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>R2 magnetic resonance imaging of the liver in patients with iron overload</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2009-05-14</date><risdate>2009</risdate><volume>113</volume><issue>20</issue><spage>4853</spage><epage>4855</epage><pages>4853-4855</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Forty-three patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>19264677</pmid><doi>10.1182/blood-2008-12-191643</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Biopsy Calibration Child Clinical Trials and Observations Female Ferritins - analysis Ferritins - blood Hematologic and hematopoietic diseases Humans Iron Overload - diagnostic imaging Iron Overload - pathology Liver - diagnostic imaging Liver - pathology Magnetic Resonance Imaging - methods Magnetic Resonance Imaging - standards Male Medical sciences Metabolic diseases Metals (hemochromatosis...) Other metabolic disorders Radiography Single-Blind Method Young Adult |
| title | R2 magnetic resonance imaging of the liver in patients with iron overload |
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