Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour

The Prader–Willi syndrome (PWS) genetic interval contains several brain-expressed small nucleolar (sno)RNA species that are subject to genomic imprinting. In vitro studies have shown that one of these snoRNA molecules, h/mbii-52, negatively regulates editing and alternative splicing of the serotonin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human molecular genetics 2009-06, Vol.18 (12), p.2140-2148
Hauptverfasser:	Doe, Christine M., Relkovic, Dinko, Garfield, Alastair S., Dalley, Jeffrey W., Theobald, David E.H., Humby, Trevor, Wilkinson, Lawrence S., Isles, Anthony R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Behavior, Animal Biological and medical sciences Brain - metabolism Brain - physiopathology Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genomic Imprinting Humans Male Mice Mice, Inbred C57BL Molecular and cellular biology Prader-Willi Syndrome - genetics Prader-Willi Syndrome - metabolism Prader-Willi Syndrome - physiopathology Receptor, Serotonin, 5-HT2C - genetics Receptor, Serotonin, 5-HT2C - metabolism RNA Editing RNA, Small Nucleolar - genetics RNA, Small Nucleolar - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!