A C-terminal silencing domain in GW182 is essential for miRNA function

Proteins of the GW182 family are essential for miRNA-mediated gene silencing in animal cells; they interact with Argonaute proteins (AGOs) and are required for both the translational repression and mRNA degradation mediated by miRNAs. To gain insight into the role of the GW182-AGO1 interaction in si...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	RNA (Cambridge) 2009-06, Vol.15 (6), p.1067-1077
Hauptverfasser:	Eulalio, Ana, Helms, Sigrun, Fritzsch, Christoph, Fauser, Maria, Izaurralde, Elisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Argonaute Proteins Autoantigens - genetics Autoantigens - metabolism Binding Sites Drosophila melanogaster - metabolism Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism Eukaryotic Initiation Factors Fluorescent Antibody Technique Gene Silencing MicroRNAs - metabolism Protein Structure, Tertiary RNA Stability Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!