Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation

Mitochondrial toxicity results from pyrimidine nucleoside reverse transcriptase inhibitors (NRTIs) for HIV/AIDS. In the heart, this can deplete mitochondrial (mt) DNA and cause cardiac dysfunction (eg, left ventricle hypertrophy, LVH). Four unique transgenic, cardiac-targeted overexpressors (TGs) we...

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Veröffentlicht in:	Laboratory investigation 2009-02, Vol.89 (2), p.122-130
Hauptverfasser:	Kohler, James J, Hosseini, Seyed H, Cucoranu, Ioan, Hoying-Brandt, Amy, Green, Elgin, Johnson, David, Wittich, Bree, Srivastava, Jaya, Ivey, Kristopher, Fields, Earl, Russ, Rodney, Raper, C Michael, Santoianni, Robert, Lewis, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-HIV Agents - toxicity Antiretroviral Therapy, Highly Active Biological and medical sciences Biotechnology Cardiomyopathy, Dilated - chemically induced Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Dilated - pathology Cell Line DNA, Mitochondrial - analysis DNA, Mitochondrial - metabolism Echocardiography Female Fundamental and applied biological sciences. Psychology Heart Ventricles - chemistry Heart Ventricles - drug effects Heart Ventricles - metabolism Human immunodeficiency virus Hypertrophy, Left Ventricular - chemically induced Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - metabolism Indinavir - toxicity Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Lamivudine - toxicity Male Medical sciences Medicine Medicine & Public Health Mice Mice, Transgenic Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Mitochondria, Heart - ultrastructure Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure Pathology Phosphorylation research-article Reverse Transcriptase Inhibitors - toxicity Thymidine Kinase - genetics Thymidine Kinase - metabolism Zidovudine - toxicity
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