An Ivermectin-Sensitive Glutamate-Gated Chloride Channel from the Parasitic Nematode Haemonchus contortus

Nematode glutamate-gated chloride channels are targets of the macrocyclic lactones, the most important group of anthelmintics available. In Xenopus laevis oocytes, channels formed by the GluClα3B subunit from the parasite Haemonchus contortus were more sensitive to l-glutamate (EC50 = 27.6 ± 2.7 μM)...

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Veröffentlicht in:	Molecular pharmacology 2009-06, Vol.75 (6), p.1347-1355
Hauptverfasser:	McCavera, Samantha, Rogers, Adrian T., Yates, Darran M., Woods, Debra J., Wolstenholme, Adrian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthelmintics - pharmacology Cercopithecus aethiops Chloride Channel Agonists Chloride Channels - genetics COS Cells Drug Resistance Female Glutamic Acid - pharmacology Haemonchus - metabolism Ion Channel Gating Ivermectin - pharmacology Models, Molecular Mutagenesis, Site-Directed Mutation Oocytes - drug effects Oocytes - physiology Patch-Clamp Techniques Protein Conformation Protein Subunits - physiology Radioligand Assay Xenopus laevis
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