HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin

Histone deacetylase 6 (HDAC6) is a tubulin-specific deacetylase that regulates microtubule-dependent cell movement. In this study, we identify the F-actin-binding protein cortactin as a HDAC6 substrate. We demonstrate that HDAC6 binds cortactin and that overexpression of HDAC6 leads to hypoacetylati...

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Veröffentlicht in:	Molecular cell 2007-07, Vol.27 (2), p.197-213
Hauptverfasser:	Zhang, Xiaohong, Yuan, Zhigang, Zhang, Yingtao, Yong, Sarah, Salas-Burgos, Alexis, Koomen, John, Olashaw, Nancy, Parsons, J. Thomas, Yang, Xiang-Jiao, Dent, Sharon R., Yao, Tso-Pang, Lane, William S., Seto, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Actins - metabolism Amino Acid Sequence Amino Acid Substitution Animals Cell Cycle Proteins - metabolism Cell Movement - physiology CELLBIO Cortactin - chemistry Cortactin - genetics Cortactin - metabolism HeLa Cells Histone Acetyltransferases - metabolism Histone Deacetylase 6 Histone Deacetylase Inhibitors Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans In Vitro Techniques Mice Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed NIH 3T3 Cells p300-CBP Transcription Factors Protein Binding PROTEINS Rabbits Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Repetitive Sequences, Amino Acid Sequence Homology, Amino Acid Transcription Factors - metabolism
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