Erbb2 Suppresses DNA Damage-Induced Checkpoint Activation and UV-Induced Mouse Skin Tumorigenesis

The Erbb2 receptor is activated by UV irradiation, the primary cause of non-melanoma skin cancer. We hypothesized that Erbb2 activation contributes to UV-induced skin tumorigenesis by suppressing cell cycle arrest. Consistent with this hypothesis, inhibition of Erbb2 in v- ras Ha transgenic mice bef...

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Veröffentlicht in:	The American journal of pathology 2009-06, Vol.174 (6), p.2357-2366
Hauptverfasser:	Madson, Justin G, Lynch, David T, Svoboda, Jessica, Ophardt, Rebecca, Yanagida, Jodi, Putta, Sumanth K, Bowles, Andrew, Trempus, Carol S, Tennant, Raymond W, Hansen, Laura A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cdc25 Phosphatases - metabolism cdc25 Phosphatases - radiation effects Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - radiation effects Checkpoint Kinase 1 DNA Damage - radiation effects Genes, cdc - radiation effects Immunoblotting Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Mice, Transgenic Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol 3-Kinases - radiation effects Phosphorylation Protein Kinases - metabolism Protein Kinases - radiation effects Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-akt - radiation effects Receptor, ErbB-2 - metabolism Regular Signal Transduction - radiation effects Skin Neoplasms - genetics Skin Neoplasms - metabolism Ultraviolet Rays
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