V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals

Background: Previous studies have suggested that a variant in the melanocortin-4 receptor (MC4R) gene is important in protecting against common obesity. Larger studies are needed, however, to confirm this relation. Methods: We assessed the association between the V103I polymorphism in the MC4R gene...

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Veröffentlicht in:	International Journal of Obesity 2007-09, Vol.31 (9), p.1437-1441
Hauptverfasser:	Young, E.H, Wareham, N.J, Farooqi, S, Hinney, A, Hebebrand, J, Scherag, A, O'Rahilly, S, Barroso, I, Sandhu, M.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles biological resistance Body Mass Index Cohort Studies disease resistance energy metabolism epidemiological studies Epidemiology etiology food intake genes Genetic aspects genetic polymorphism Genetic polymorphisms Genetic Predisposition to Disease genetic variation Genetics, Population Health aspects Health Promotion and Disease Prevention Heterogeneity Heterozygote human genetics Humans Internal Medicine isoleucine Male Medicine Medicine & Public Health melanocortin-4 receptor gene meta-analysis Metabolic Diseases Middle Aged Obesity Obesity - genetics original-article Phenotype physiological regulation Pituitary hormones Polymorphism, Genetic population genetics Population-based studies protective effect Public Health Receptor, Melanocortin, Type 4 - genetics receptors risk assessment Risk factors Systematic review
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