Tissue Distribution, Gender-Divergent Expression, Ontogeny, and Chemical Induction of Multidrug Resistance Transporter Genes (Mdr1a, Mdr1b, Mdr2) in Mice

Multidrug resistance (Mdr) transporters are ATP-binding cassette transporters that efflux amphipathic cations from cells and protect tissues from xenobiotics. Unfortunately, Mdr transporters also efflux anticancer drugs from some tumor cells, resulting in multidrug resistance. There are two groups o...

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Veröffentlicht in:	Drug metabolism and disposition 2009-01, Vol.37 (1), p.203-210
Hauptverfasser:	Cui, Yue Julia, Cheng, Xingguo, Weaver, Yi Miao, Klaassen, Curtis D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Female Genes, MDR Gonads - surgery Hypophysectomy Male Medical sciences Mice Mice, Inbred C57BL Pharmacology. Drug treatments RNA, Messenger - genetics RNA, Messenger - metabolism Sex Factors
Online-Zugang:	Volltext
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