Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats

Background/Aims Non-alcoholic fatty liver disease (NAFLD) is a common health problem and includes a spectrum of hepatic steatosis, steatohepatitis and fibrosis. The renin–angiotensin system (RAS) plays a vital role in blood pressure regulation and appears to promote hepatic fibrogenesis. We hypothes...

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Veröffentlicht in:	Journal of hepatology 2008-09, Vol.49 (3), p.417-428
Hauptverfasser:	Wei, Yongzhong, Clark, Suzanne E, Morris, E. Matthew, Thyfault, John P, Uptergrove, Grace M.E, Whaley-Connell, Adam T, Ferrario, Carlos M, Sowers, James R, Ibdah, Jamal A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Angiotensin II - physiology Animals Animals, Genetically Modified Antihypertensive Agents - pharmacology Antioxidants - pharmacology Apoptosis - drug effects Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Cyclic N-Oxides - pharmacology Disease Models, Animal Fatty Liver - metabolism Fatty Liver - physiopathology Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Non-alcoholic fatty liver disease Other diseases. Semiology Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Renin - genetics Renin - metabolism Renin - physiology Renin-Angiotensin System - drug effects Renin-Angiotensin System - physiology Spin Labels Tetrazoles - pharmacology Valine - analogs & derivatives Valine - pharmacology Valsartan
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