On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites
Summary The generation of protective immunity to helminth parasites is critically dependent upon the development of a CD4+ T helper type 2 cytokine response. However, the host–parasite interactions responsible for initiating this response are poorly understood. This review will discuss recent advanc...
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| Veröffentlicht in: | Cellular microbiology 2008-09, Vol.10 (9), p.1757-1764 |
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| creator | Perrigoue, Jacqueline G. Marshall, Fraser A. Artis, David |
| description | Summary
The generation of protective immunity to helminth parasites is critically dependent upon the development of a CD4+ T helper type 2 cytokine response. However, the host–parasite interactions responsible for initiating this response are poorly understood. This review will discuss recent advances in our understanding of how helminth‐derived products are recognized by innate immune cells. Specifically, interactions between helminth excretory/secretory products and host Toll‐like receptors and lectins will be discussed as well as the putative functions of helminth proteases and chitin in activating and recruiting innate immune cells. In addition, the functional significance of pattern recognition by epithelial cells, granulocytes, dendritic cells and macrophages including expression of alarmins, thymic stromal lymphopoetin, interleukin (IL)‐25, IL‐33 and Notch ligands in the development of adaptive anti‐parasite Th2 cytokine responses will be examined. |
| doi_str_mv | 10.1111/j.1462-5822.2008.01174.x |
| format | Article |
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The generation of protective immunity to helminth parasites is critically dependent upon the development of a CD4+ T helper type 2 cytokine response. However, the host–parasite interactions responsible for initiating this response are poorly understood. This review will discuss recent advances in our understanding of how helminth‐derived products are recognized by innate immune cells. Specifically, interactions between helminth excretory/secretory products and host Toll‐like receptors and lectins will be discussed as well as the putative functions of helminth proteases and chitin in activating and recruiting innate immune cells. In addition, the functional significance of pattern recognition by epithelial cells, granulocytes, dendritic cells and macrophages including expression of alarmins, thymic stromal lymphopoetin, interleukin (IL)‐25, IL‐33 and Notch ligands in the development of adaptive anti‐parasite Th2 cytokine responses will be examined.</description><identifier>ISSN: 1462-5814</identifier><identifier>EISSN: 1462-5822</identifier><identifier>DOI: 10.1111/j.1462-5822.2008.01174.x</identifier><identifier>PMID: 18505479</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Chitin - immunology ; Chitin - metabolism ; Helminth Proteins - immunology ; Helminth Proteins - metabolism ; Helminthiasis - immunology ; Helminths - immunology ; Helminths - metabolism ; Host-Parasite Interactions - immunology ; Humans ; Immunity, Innate ; Lectins - immunology ; Lectins - metabolism ; Peptide Hydrolases - immunology ; Peptide Hydrolases - metabolism ; Th2 Cells - immunology ; Toll-Like Receptors - immunology</subject><ispartof>Cellular microbiology, 2008-09, Vol.10 (9), p.1757-1764</ispartof><rights>2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd</rights><rights>2008 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5654-256f36918cd19f1d6d86c30c3aac382ed4d3fea32d61bbf0971ec54897fc6f403</citedby><cites>FETCH-LOGICAL-c5654-256f36918cd19f1d6d86c30c3aac382ed4d3fea32d61bbf0971ec54897fc6f403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1462-5822.2008.01174.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1462-5822.2008.01174.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18505479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perrigoue, Jacqueline G.</creatorcontrib><creatorcontrib>Marshall, Fraser A.</creatorcontrib><creatorcontrib>Artis, David</creatorcontrib><title>On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites</title><title>Cellular microbiology</title><addtitle>Cell Microbiol</addtitle><description>Summary
The generation of protective immunity to helminth parasites is critically dependent upon the development of a CD4+ T helper type 2 cytokine response. However, the host–parasite interactions responsible for initiating this response are poorly understood. This review will discuss recent advances in our understanding of how helminth‐derived products are recognized by innate immune cells. Specifically, interactions between helminth excretory/secretory products and host Toll‐like receptors and lectins will be discussed as well as the putative functions of helminth proteases and chitin in activating and recruiting innate immune cells. In addition, the functional significance of pattern recognition by epithelial cells, granulocytes, dendritic cells and macrophages including expression of alarmins, thymic stromal lymphopoetin, interleukin (IL)‐25, IL‐33 and Notch ligands in the development of adaptive anti‐parasite Th2 cytokine responses will be examined.</description><subject>Animals</subject><subject>Chitin - immunology</subject><subject>Chitin - metabolism</subject><subject>Helminth Proteins - immunology</subject><subject>Helminth Proteins - metabolism</subject><subject>Helminthiasis - immunology</subject><subject>Helminths - immunology</subject><subject>Helminths - metabolism</subject><subject>Host-Parasite Interactions - immunology</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Lectins - immunology</subject><subject>Lectins - metabolism</subject><subject>Peptide Hydrolases - immunology</subject><subject>Peptide Hydrolases - metabolism</subject><subject>Th2 Cells - immunology</subject><subject>Toll-Like Receptors - immunology</subject><issn>1462-5814</issn><issn>1462-5822</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhS0EoqXwF5DFgt0Ev-MggYRGPCq16qasLY8fjUeJPdhJaf89Tmc00K7wxvf6fvfIRwcAiFGD6_mwbTATZMUlIQ1BSDYI45Y1d8_A6XHw_FhjdgJelbJFCIsW45fgBEuOOGu7U2CvIpx6B_s5TtCnDHs3jCFOffkIQ4x6cjCM4xwdNG4YSn17wLMz6SaGKaQIdbS1L7sUi4NTOirAnc66hMmV1-CF10Nxbw73Gfj57ev1-sfq4ur7-frLxcpwwdmKcOGp6LA0FnceW2GlMBQZqrWhkjjLLPVOU2IF3mw86lrsDGeya70RniF6Bj7vdXfzZnTWuDhlPahdDqPO9yrpoB5PYujVTbpVREhKW1IF3h8Ecvo1uzKpMZTFuI4uzUWJjlMhOlHBd0_AbZpzrOYUQZR3mDJWIbmHTE6lZOePP8FILTmqrVoiUktcaslRPeSo7urq23-d_F08BFeBT3vgdxjc_X8Lq_Xl-VLRP5Dfrew</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Perrigoue, Jacqueline G.</creator><creator>Marshall, Fraser A.</creator><creator>Artis, David</creator><general>Blackwell Publishing Ltd</general><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200809</creationdate><title>On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites</title><author>Perrigoue, Jacqueline G. ; Marshall, Fraser A. ; Artis, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5654-256f36918cd19f1d6d86c30c3aac382ed4d3fea32d61bbf0971ec54897fc6f403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Chitin - immunology</topic><topic>Chitin - metabolism</topic><topic>Helminth Proteins - immunology</topic><topic>Helminth Proteins - metabolism</topic><topic>Helminthiasis - immunology</topic><topic>Helminths - immunology</topic><topic>Helminths - metabolism</topic><topic>Host-Parasite Interactions - immunology</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Lectins - immunology</topic><topic>Lectins - metabolism</topic><topic>Peptide Hydrolases - immunology</topic><topic>Peptide Hydrolases - metabolism</topic><topic>Th2 Cells - immunology</topic><topic>Toll-Like Receptors - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perrigoue, Jacqueline G.</creatorcontrib><creatorcontrib>Marshall, Fraser A.</creatorcontrib><creatorcontrib>Artis, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perrigoue, Jacqueline G.</au><au>Marshall, Fraser A.</au><au>Artis, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites</atitle><jtitle>Cellular microbiology</jtitle><addtitle>Cell Microbiol</addtitle><date>2008-09</date><risdate>2008</risdate><volume>10</volume><issue>9</issue><spage>1757</spage><epage>1764</epage><pages>1757-1764</pages><issn>1462-5814</issn><eissn>1462-5822</eissn><abstract>Summary
The generation of protective immunity to helminth parasites is critically dependent upon the development of a CD4+ T helper type 2 cytokine response. However, the host–parasite interactions responsible for initiating this response are poorly understood. This review will discuss recent advances in our understanding of how helminth‐derived products are recognized by innate immune cells. Specifically, interactions between helminth excretory/secretory products and host Toll‐like receptors and lectins will be discussed as well as the putative functions of helminth proteases and chitin in activating and recruiting innate immune cells. In addition, the functional significance of pattern recognition by epithelial cells, granulocytes, dendritic cells and macrophages including expression of alarmins, thymic stromal lymphopoetin, interleukin (IL)‐25, IL‐33 and Notch ligands in the development of adaptive anti‐parasite Th2 cytokine responses will be examined.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18505479</pmid><doi>10.1111/j.1462-5822.2008.01174.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cellular microbiology, 2008-09, Vol.10 (9), p.1757-1764 |
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| source | MEDLINE; Wiley Journals; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); Alma/SFX Local Collection |
| subjects | Animals Chitin - immunology Chitin - metabolism Helminth Proteins - immunology Helminth Proteins - metabolism Helminthiasis - immunology Helminths - immunology Helminths - metabolism Host-Parasite Interactions - immunology Humans Immunity, Innate Lectins - immunology Lectins - metabolism Peptide Hydrolases - immunology Peptide Hydrolases - metabolism Th2 Cells - immunology Toll-Like Receptors - immunology |
| title | On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites |
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