Post-weaning social isolation alters anxiety-related behavior and neurochemical gene expression in the brain of male prairie voles
Stressful social experiences early in life, such as maternal separation and social isolation, have enduring effects on the development of the brain and behavior. In the present study in socially monogamous male prairie voles ( Microtus ochrogaster), we found that following 6 weeks of social isolatio...
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| Veröffentlicht in: | Neuroscience letters 2009-04, Vol.454 (1), p.67-71 |
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| creator | Pan, Yongliang Liu, Yan Young, Kimberly A. Zhang, Zhibin Wang, Zuoxin |
| description | Stressful social experiences early in life, such as maternal separation and social isolation, have enduring effects on the development of the brain and behavior. In the present study in socially monogamous male prairie voles (
Microtus ochrogaster), we found that following 6 weeks of social isolation after weaning males spent more time in the closed arms and less time in the open arms during an elevated plus maze (EPM) test, moved more frequently from central to peripheral squares in an open field test, and diminished their preferences for the empty chamber during a two-chamber affiliation test, compared to control males that were housed with siblings. This increased behavioral anxiety in socially isolated males was also associated with enhanced mRNA expression for vasopressin (AVP), oxytocin (OT), corticotrophin releasing factor (CRF), and tyrosine hydroxylase (TH) in the paraventricular nucleus of the hypothalamus (PVN). Together, these data illustrate the importance of the post-weaning social environment on anxiety-related behavior and suggest a potential role of neurochemical systems in the PVN in the regulation of this behavior. |
| doi_str_mv | 10.1016/j.neulet.2009.02.064 |
| format | Article |
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Microtus ochrogaster), we found that following 6 weeks of social isolation after weaning males spent more time in the closed arms and less time in the open arms during an elevated plus maze (EPM) test, moved more frequently from central to peripheral squares in an open field test, and diminished their preferences for the empty chamber during a two-chamber affiliation test, compared to control males that were housed with siblings. This increased behavioral anxiety in socially isolated males was also associated with enhanced mRNA expression for vasopressin (AVP), oxytocin (OT), corticotrophin releasing factor (CRF), and tyrosine hydroxylase (TH) in the paraventricular nucleus of the hypothalamus (PVN). Together, these data illustrate the importance of the post-weaning social environment on anxiety-related behavior and suggest a potential role of neurochemical systems in the PVN in the regulation of this behavior.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2009.02.064</identifier><identifier>PMID: 19429056</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Anxiety - etiology ; Anxiety - genetics ; Anxiety - physiopathology ; Arvicolinae ; Autoradiography ; Behavior, Animal ; Biological and medical sciences ; Brain - metabolism ; Corticotropin releasing factor ; Corticotropin-Releasing Hormone - biosynthesis ; Elevated plus maze ; Fundamental and applied biological sciences. Psychology ; Gene Expression - physiology ; Male ; Microtus ; Microtus ochrogaster ; Oxytocin ; Oxytocin - biosynthesis ; PVN ; RNA, Messenger - analysis ; Social Isolation - psychology ; Stress, Psychological - genetics ; Stress, Psychological - physiopathology ; Tyrosine 3-Monooxygenase - biosynthesis ; Tyrosine hydroxylase ; Vasopressin ; Vasopressins - biosynthesis ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2009-04, Vol.454 (1), p.67-71</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-bb000c8d2c0826eb51f68184d77973133b511432791f470fde6241c1add7627f3</citedby><cites>FETCH-LOGICAL-c522t-bb000c8d2c0826eb51f68184d77973133b511432791f470fde6241c1add7627f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394009002559$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21375460$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19429056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pan, Yongliang</creatorcontrib><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Young, Kimberly A.</creatorcontrib><creatorcontrib>Zhang, Zhibin</creatorcontrib><creatorcontrib>Wang, Zuoxin</creatorcontrib><title>Post-weaning social isolation alters anxiety-related behavior and neurochemical gene expression in the brain of male prairie voles</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Stressful social experiences early in life, such as maternal separation and social isolation, have enduring effects on the development of the brain and behavior. In the present study in socially monogamous male prairie voles (
Microtus ochrogaster), we found that following 6 weeks of social isolation after weaning males spent more time in the closed arms and less time in the open arms during an elevated plus maze (EPM) test, moved more frequently from central to peripheral squares in an open field test, and diminished their preferences for the empty chamber during a two-chamber affiliation test, compared to control males that were housed with siblings. This increased behavioral anxiety in socially isolated males was also associated with enhanced mRNA expression for vasopressin (AVP), oxytocin (OT), corticotrophin releasing factor (CRF), and tyrosine hydroxylase (TH) in the paraventricular nucleus of the hypothalamus (PVN). Together, these data illustrate the importance of the post-weaning social environment on anxiety-related behavior and suggest a potential role of neurochemical systems in the PVN in the regulation of this behavior.</description><subject>Animals</subject><subject>Anxiety - etiology</subject><subject>Anxiety - genetics</subject><subject>Anxiety - physiopathology</subject><subject>Arvicolinae</subject><subject>Autoradiography</subject><subject>Behavior, Animal</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Corticotropin releasing factor</subject><subject>Corticotropin-Releasing Hormone - biosynthesis</subject><subject>Elevated plus maze</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression - physiology</subject><subject>Male</subject><subject>Microtus</subject><subject>Microtus ochrogaster</subject><subject>Oxytocin</subject><subject>Oxytocin - biosynthesis</subject><subject>PVN</subject><subject>RNA, Messenger - analysis</subject><subject>Social Isolation - psychology</subject><subject>Stress, Psychological - genetics</subject><subject>Stress, Psychological - physiopathology</subject><subject>Tyrosine 3-Monooxygenase - biosynthesis</subject><subject>Tyrosine hydroxylase</subject><subject>Vasopressin</subject><subject>Vasopressins - biosynthesis</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcGOFCEUJEbjjqN_YAwXvXULNA3dFxOzcdVkEz3omdD06xkmNIzAzO5e98ulM5NdveiBAO9VVeq9Qug1JTUlVLzf1R4ODnLNCOlrwmoi-BO0op1klewle4pWpCG8anpOLtCLlHaEkJa2_Dm6oD1nPWnFCt1_DylXN6C99RucgrHaYZuC09kGj7XLEBPW_tZCvqsilDqMeICtPtoQS2PExUYMZguzNYW7AQ8YbvcRUloUrMd5C3iIurzChGftAO_LL1rAx-AgvUTPJu0SvDrfa_Tz6tOPyy_V9bfPXy8_XlemZSxXw1D8m25khnRMwNDSSXS046Ms0za0aUqF8obJnk5ckmkEwTg1VI-jFExOzRp9OOnuD8MMowGfo3ZqH-2s450K2qq_O95u1SYcFRNds5w1encWiOHXAVJWs00GnNMewiEpIRljopX_BTLSiZ7zRZGfgCaGlCJMD24oUUvKaqdOKaslZUWYKikX2ps_J3kknWMtgLdngE4llClqb2x6wDHayJYL8rgSKHs_WogqGQvewGgjmKzGYP_t5Ddetsq_</recordid><startdate>20090417</startdate><enddate>20090417</enddate><creator>Pan, Yongliang</creator><creator>Liu, Yan</creator><creator>Young, Kimberly A.</creator><creator>Zhang, Zhibin</creator><creator>Wang, Zuoxin</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090417</creationdate><title>Post-weaning social isolation alters anxiety-related behavior and neurochemical gene expression in the brain of male prairie voles</title><author>Pan, Yongliang ; Liu, Yan ; Young, Kimberly A. ; Zhang, Zhibin ; Wang, Zuoxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-bb000c8d2c0826eb51f68184d77973133b511432791f470fde6241c1add7627f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Anxiety - etiology</topic><topic>Anxiety - genetics</topic><topic>Anxiety - physiopathology</topic><topic>Arvicolinae</topic><topic>Autoradiography</topic><topic>Behavior, Animal</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Corticotropin releasing factor</topic><topic>Corticotropin-Releasing Hormone - biosynthesis</topic><topic>Elevated plus maze</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression - physiology</topic><topic>Male</topic><topic>Microtus</topic><topic>Microtus ochrogaster</topic><topic>Oxytocin</topic><topic>Oxytocin - biosynthesis</topic><topic>PVN</topic><topic>RNA, Messenger - analysis</topic><topic>Social Isolation - psychology</topic><topic>Stress, Psychological - genetics</topic><topic>Stress, Psychological - physiopathology</topic><topic>Tyrosine 3-Monooxygenase - biosynthesis</topic><topic>Tyrosine hydroxylase</topic><topic>Vasopressin</topic><topic>Vasopressins - biosynthesis</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pan, Yongliang</creatorcontrib><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Young, Kimberly A.</creatorcontrib><creatorcontrib>Zhang, Zhibin</creatorcontrib><creatorcontrib>Wang, Zuoxin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pan, Yongliang</au><au>Liu, Yan</au><au>Young, Kimberly A.</au><au>Zhang, Zhibin</au><au>Wang, Zuoxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-weaning social isolation alters anxiety-related behavior and neurochemical gene expression in the brain of male prairie voles</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2009-04-17</date><risdate>2009</risdate><volume>454</volume><issue>1</issue><spage>67</spage><epage>71</epage><pages>67-71</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Stressful social experiences early in life, such as maternal separation and social isolation, have enduring effects on the development of the brain and behavior. In the present study in socially monogamous male prairie voles (
Microtus ochrogaster), we found that following 6 weeks of social isolation after weaning males spent more time in the closed arms and less time in the open arms during an elevated plus maze (EPM) test, moved more frequently from central to peripheral squares in an open field test, and diminished their preferences for the empty chamber during a two-chamber affiliation test, compared to control males that were housed with siblings. This increased behavioral anxiety in socially isolated males was also associated with enhanced mRNA expression for vasopressin (AVP), oxytocin (OT), corticotrophin releasing factor (CRF), and tyrosine hydroxylase (TH) in the paraventricular nucleus of the hypothalamus (PVN). Together, these data illustrate the importance of the post-weaning social environment on anxiety-related behavior and suggest a potential role of neurochemical systems in the PVN in the regulation of this behavior.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19429056</pmid><doi>10.1016/j.neulet.2009.02.064</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anxiety - etiology Anxiety - genetics Anxiety - physiopathology Arvicolinae Autoradiography Behavior, Animal Biological and medical sciences Brain - metabolism Corticotropin releasing factor Corticotropin-Releasing Hormone - biosynthesis Elevated plus maze Fundamental and applied biological sciences. Psychology Gene Expression - physiology Male Microtus Microtus ochrogaster Oxytocin Oxytocin - biosynthesis PVN RNA, Messenger - analysis Social Isolation - psychology Stress, Psychological - genetics Stress, Psychological - physiopathology Tyrosine 3-Monooxygenase - biosynthesis Tyrosine hydroxylase Vasopressin Vasopressins - biosynthesis Vertebrates: nervous system and sense organs |
| title | Post-weaning social isolation alters anxiety-related behavior and neurochemical gene expression in the brain of male prairie voles |
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