PICK1-mediated Glutamate Receptor Subunit 2 (GluR2) Trafficking Contributes to Cell Death in Oxygen/Glucose-deprived Hippocampal Neurons

Oxygen and glucose deprivation (OGD) induces delayed cell death in hippocampal CA1 neurons via Ca2+/Zn2+-permeable, GluR2-lacking AMPA receptors (AMPARs). Following OGD, synaptic AMPAR currents in hippocampal neurons show marked inward rectification and increased sensitivity to channel blockers sele...

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Veröffentlicht in:	The Journal of biological chemistry 2009-05, Vol.284 (21), p.14230-14235
Hauptverfasser:	Dixon, Rebecca M., Mellor, Jack R., Hanley, Jonathan G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - chemistry Carrier Proteins - metabolism Cell Death Cell Membrane - metabolism Cytoskeletal Proteins Excitatory Postsynaptic Potentials Glucose - deficiency Hippocampus - cytology Male Membrane Transport, Structure, Function, and Biogenesis Neurons - cytology Neurons - metabolism Nuclear Proteins - chemistry Nuclear Proteins - metabolism Oxygen - metabolism Protein Structure, Tertiary Protein Subunits - metabolism Protein Transport Rats Rats, Wistar Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - metabolism
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