Validated liquid chromatographic–electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-methoxymethamphetamine in squirrel monkey plasma

3,4-Methylenedioxymethamphetamine (MDMA) is a recreational drug with neurotoxic potential. Pharmacokinetic data of MDMA and its metabolites may shed light on the mechanism of MDMA neurotoxicity. An LC–MS assay with electrospray ionization (ESI) is presented for quantifying MDMA and its metabolites 3...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2007-08, Vol.855 (2), p.262-270
Hauptverfasser:	Mueller, Melanie, Peters, Frank T., Ricaurte, George A., Maurer, Hans H.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Methylenedioxyamphetamine - analogs & derivatives 3,4-Methylenedioxyamphetamine - blood 3,4-Methylenedioxyamphetamine - isolation & purification Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Calibration Chromatography, Liquid - methods Deoxyepinephrine - analogs & derivatives Deoxyepinephrine - blood Deoxyepinephrine - isolation & purification Fundamental and applied biological sciences. Psychology General pharmacology Hallucinogens - blood Hallucinogens - isolation & purification LC–ESI-MS MDMA Medical sciences Metabolites Methamphetamine - analogs & derivatives Methamphetamine - blood Methamphetamine - isolation & purification N-Methyl-3,4-methylenedioxyamphetamine - blood N-Methyl-3,4-methylenedioxyamphetamine - isolation & purification Neurotoxicity Pharmacology. Drug treatments Plasma Saimiri Spectrometry, Mass, Electrospray Ionization - methods Validation
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