Olfactory Cilia: Linking Sensory Cilia Function and Human Disease
The olfactory system gives us an awareness of our immediate environment by allowing us to detect airborne stimuli. The components necessary for detection of these odorants are compartmentalized in the cilia of olfactory sensory neurons. Cilia are microtubule-based organelles, which can be found proj...
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| Veröffentlicht in: | Chemical senses 2009-06, Vol.34 (5), p.451-464 |
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| creator | Jenkins, Paul M. McEwen, Dyke P. Martens, Jeffrey R. |
| description | The olfactory system gives us an awareness of our immediate environment by allowing us to detect airborne stimuli. The components necessary for detection of these odorants are compartmentalized in the cilia of olfactory sensory neurons. Cilia are microtubule-based organelles, which can be found projecting from the surface of almost any mammalian cell, and are critical for proper olfactory function. Mislocalization of ciliary proteins and/or the loss of cilia cause impaired olfactory function, which is now recognized as a clinical manifestation of a broad class of human diseases, termed ciliopathies. Future work investigating the mechanisms of olfactory cilia function will provide us important new information regarding the pathogenesis of human sensory perception diseases. |
| doi_str_mv | 10.1093/chemse/bjp020 |
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The components necessary for detection of these odorants are compartmentalized in the cilia of olfactory sensory neurons. Cilia are microtubule-based organelles, which can be found projecting from the surface of almost any mammalian cell, and are critical for proper olfactory function. Mislocalization of ciliary proteins and/or the loss of cilia cause impaired olfactory function, which is now recognized as a clinical manifestation of a broad class of human diseases, termed ciliopathies. Future work investigating the mechanisms of olfactory cilia function will provide us important new information regarding the pathogenesis of human sensory perception diseases.</description><identifier>ISSN: 0379-864X</identifier><identifier>EISSN: 1464-3553</identifier><identifier>DOI: 10.1093/chemse/bjp020</identifier><identifier>PMID: 19406873</identifier><identifier>CODEN: CHSED8</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>anosmia ; Biological and medical sciences ; cilia ; Cilia - genetics ; Cilia - physiology ; Cilia - ultrastructure ; ciliopathies ; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction ; Fundamental and applied biological sciences. Psychology ; Humans ; Medical sciences ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Olfaction Disorders - genetics ; Olfaction Disorders - metabolism ; Olfaction. Taste ; olfactory ; Olfactory Pathways - physiology ; Olfactory Receptor Neurons - ultrastructure ; Perception ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Smell - physiology ; trafficking</subject><ispartof>Chemical senses, 2009-06, Vol.34 (5), p.451-464</ispartof><rights>The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org 2009</rights><rights>2009 INIST-CNRS</rights><rights>The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-6cc9a8050c9979a3b7b05066a23ca1e4cb5966961ad0d4c3c22b070c30bf4aa93</citedby><cites>FETCH-LOGICAL-c610t-6cc9a8050c9979a3b7b05066a23ca1e4cb5966961ad0d4c3c22b070c30bf4aa93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21440649$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19406873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jenkins, Paul M.</creatorcontrib><creatorcontrib>McEwen, Dyke P.</creatorcontrib><creatorcontrib>Martens, Jeffrey R.</creatorcontrib><title>Olfactory Cilia: Linking Sensory Cilia Function and Human Disease</title><title>Chemical senses</title><addtitle>Chem Senses</addtitle><description>The olfactory system gives us an awareness of our immediate environment by allowing us to detect airborne stimuli. The components necessary for detection of these odorants are compartmentalized in the cilia of olfactory sensory neurons. Cilia are microtubule-based organelles, which can be found projecting from the surface of almost any mammalian cell, and are critical for proper olfactory function. Mislocalization of ciliary proteins and/or the loss of cilia cause impaired olfactory function, which is now recognized as a clinical manifestation of a broad class of human diseases, termed ciliopathies. Future work investigating the mechanisms of olfactory cilia function will provide us important new information regarding the pathogenesis of human sensory perception diseases.</description><subject>anosmia</subject><subject>Biological and medical sciences</subject><subject>cilia</subject><subject>Cilia - genetics</subject><subject>Cilia - physiology</subject><subject>Cilia - ultrastructure</subject><subject>ciliopathies</subject><subject>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Olfaction Disorders - genetics</subject><subject>Olfaction Disorders - metabolism</subject><subject>Olfaction. Taste</subject><subject>olfactory</subject><subject>Olfactory Pathways - physiology</subject><subject>Olfactory Receptor Neurons - ultrastructure</subject><subject>Perception</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Smell - physiology</subject><subject>trafficking</subject><issn>0379-864X</issn><issn>1464-3553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtr3DAURkVpaKZJl90WU0jpxo1elq0uCunkMYWBLJKW0I241siJJrY0keyS_PtqsJk-NlkJSYdPR_dD6C3BnwiW7FjfmS6a43q9wRS_QDPCBc9ZUbCXaIZZKfNK8Jt99DrGNcaEM1q9QvtEciyqks3QyWXbgO59eMrmtrXwOVtad2_dbXZlXNwdZ-eD0731LgO3yhZDBy47tdFANIdor4E2mjfTeoC-n59dzxf58vLi2_xkmWtBcJ8LrSVUuMBaylICq8s6bYQAyjQQw3VdSCGkILDCK66ZprTGJdYM1w0HkOwAfRlzN0PdmZU2rg_Qqk2wHYQn5cGqf2-cvVO3_peioqKcFyngwxQQ_MNgYq86G7VpW3DGD1GJknImRPksSJM2I2Sr9P4_cO2H4NIUFJGSFrIqqgTlI6SDjzGYZqdMsNpWqMYK1Vhh4t_9_c8_9NRZAo4mAKKGtgngtI07jhKeQL61-zhyftg8--bkaGNvHncwhPs0FVYWanHzU10v5BL_EF_VBfsN1DHCZQ</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Jenkins, Paul M.</creator><creator>McEwen, Dyke P.</creator><creator>Martens, Jeffrey R.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090601</creationdate><title>Olfactory Cilia: Linking Sensory Cilia Function and Human Disease</title><author>Jenkins, Paul M. ; McEwen, Dyke P. ; Martens, Jeffrey R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-6cc9a8050c9979a3b7b05066a23ca1e4cb5966961ad0d4c3c22b070c30bf4aa93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>anosmia</topic><topic>Biological and medical sciences</topic><topic>cilia</topic><topic>Cilia - genetics</topic><topic>Cilia - physiology</topic><topic>Cilia - ultrastructure</topic><topic>ciliopathies</topic><topic>Cranial nerves. 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| subjects | anosmia Biological and medical sciences cilia Cilia - genetics Cilia - physiology Cilia - ultrastructure ciliopathies Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Fundamental and applied biological sciences. Psychology Humans Medical sciences Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Olfaction Disorders - genetics Olfaction Disorders - metabolism Olfaction. Taste olfactory Olfactory Pathways - physiology Olfactory Receptor Neurons - ultrastructure Perception Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Smell - physiology trafficking |
| title | Olfactory Cilia: Linking Sensory Cilia Function and Human Disease |
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