Reverse Genetic Analysis of Caenorhabditis elegans Presenilins Reveals Redundant but Unequal Roles for sel-12 and hop-1 in Notch-Pathway Signaling

Mutations in the human presenilin genes PS1 and PS2 cause early-onset Alzheimer's disease. Studies in Caenorhabditis elegans and in mice indicate that one function of presenilin genes is to facilitate Notch-pathway signaling. Notably, mutations in the C. elegans presenilin gene sel-12 reduce si...

Ausführliche Beschreibung