PGC-1α and ERRα target gene downregulation is a signature of the failing human heart

Abstract Heart failure is a cause of significant morbidity and mortality in developed nations, and results from a complex interplay between genetic and environmental factors. To discover gene regulatory networks underlying heart failure, we analyzed DNA microarray data based on left ventricular free...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of molecular and cellular cardiology 2009-02, Vol.46 (2), p.201-212
Hauptverfasser:	Sihag, Smita, Cresci, Sharon, Li, Allie Y, Sucharov, Carmen C, Lehman, John J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiovascular ERK ERRα Fatty acid oxidation Gene expression profiling Heart failure LCAD Mitochondria PGC-1α Raf-1
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!