Tlx1 and Tlx3 Coordinate Specification of Dorsal Horn Pain-Modulatory Peptidergic Neurons
The dorsal spinal cord synthesizes a variety of neuropeptides that modulate the transmission of nociceptive sensory information. Here, we used genetic fate mapping to show that Tlx3(+) spinal cord neurons and their derivatives represent a heterogeneous population of neurons, marked by partially over...
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| Veröffentlicht in: | The Journal of neuroscience 2008-04, Vol.28 (15), p.4037-4046 |
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| creator | Xu, Yi Lopes, Claudia Qian, Ying Liu, Ying Cheng, Leping Goulding, Martyn Turner, Eric E Lima, Deolinda Ma, Qiufu |
| description | The dorsal spinal cord synthesizes a variety of neuropeptides that modulate the transmission of nociceptive sensory information. Here, we used genetic fate mapping to show that Tlx3(+) spinal cord neurons and their derivatives represent a heterogeneous population of neurons, marked by partially overlapping expression of a set of neuropeptide genes, including those encoding the anti-opioid peptide cholecystokinin, pronociceptive Substance P (SP), Neurokinin B, and a late wave of somatostatin. Mutations of Tlx3 and Tlx1 result in a loss of expression of these peptide genes. Brn3a, a homeobox transcription factor, the expression of which is partly dependent on Tlx3, is required specifically for the early wave of SP expression. These studies suggest that Tlx1 and Tlx3 operate high in the regulatory hierarchy that coordinates specification of dorsal horn pain-modulatory peptidergic neurons. |
| doi_str_mv | 10.1523/JNEUROSCI.4126-07.2008 |
| format | Article |
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Here, we used genetic fate mapping to show that Tlx3(+) spinal cord neurons and their derivatives represent a heterogeneous population of neurons, marked by partially overlapping expression of a set of neuropeptide genes, including those encoding the anti-opioid peptide cholecystokinin, pronociceptive Substance P (SP), Neurokinin B, and a late wave of somatostatin. Mutations of Tlx3 and Tlx1 result in a loss of expression of these peptide genes. Brn3a, a homeobox transcription factor, the expression of which is partly dependent on Tlx3, is required specifically for the early wave of SP expression. These studies suggest that Tlx1 and Tlx3 operate high in the regulatory hierarchy that coordinates specification of dorsal horn pain-modulatory peptidergic neurons.</description><identifier>ISSN: 0270-6474</identifier><identifier>EISSN: 1529-2401</identifier><identifier>DOI: 10.1523/JNEUROSCI.4126-07.2008</identifier><identifier>PMID: 18400903</identifier><language>eng</language><publisher>United States: Soc Neuroscience</publisher><subject>Aging - metabolism ; Animals ; Animals, Newborn ; Cholecystokinin - metabolism ; Embryo, Mammalian - metabolism ; Gene Expression Regulation ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Mice ; Mice, Transgenic ; Mutation ; Neurokinin B - metabolism ; Neurons - metabolism ; Neuropeptides - genetics ; Neuropeptides - metabolism ; Pain - metabolism ; Pain - physiopathology ; PAX2 Transcription Factor - metabolism ; Somatostatin - metabolism ; Spinal Cord - embryology ; Spinal Cord - metabolism ; Substance P - metabolism ; Transcription Factor Brn-3A - genetics ; Transcription Factor Brn-3A - metabolism ; Transcription, Genetic</subject><ispartof>The Journal of neuroscience, 2008-04, Vol.28 (15), p.4037-4046</ispartof><rights>Copyright © 2008 Society for Neuroscience 0270-6474/08/284037-10$15.00/0 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-90ef9c608798f17d7cc80f0ed7b566e2d65b44f95f02557905a885b8dba1ac563</citedby><cites>FETCH-LOGICAL-c594t-90ef9c608798f17d7cc80f0ed7b566e2d65b44f95f02557905a885b8dba1ac563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681187/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681187/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18400903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Yi</creatorcontrib><creatorcontrib>Lopes, Claudia</creatorcontrib><creatorcontrib>Qian, Ying</creatorcontrib><creatorcontrib>Liu, Ying</creatorcontrib><creatorcontrib>Cheng, Leping</creatorcontrib><creatorcontrib>Goulding, Martyn</creatorcontrib><creatorcontrib>Turner, Eric E</creatorcontrib><creatorcontrib>Lima, Deolinda</creatorcontrib><creatorcontrib>Ma, Qiufu</creatorcontrib><title>Tlx1 and Tlx3 Coordinate Specification of Dorsal Horn Pain-Modulatory Peptidergic Neurons</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>The dorsal spinal cord synthesizes a variety of neuropeptides that modulate the transmission of nociceptive sensory information. Here, we used genetic fate mapping to show that Tlx3(+) spinal cord neurons and their derivatives represent a heterogeneous population of neurons, marked by partially overlapping expression of a set of neuropeptide genes, including those encoding the anti-opioid peptide cholecystokinin, pronociceptive Substance P (SP), Neurokinin B, and a late wave of somatostatin. Mutations of Tlx3 and Tlx1 result in a loss of expression of these peptide genes. Brn3a, a homeobox transcription factor, the expression of which is partly dependent on Tlx3, is required specifically for the early wave of SP expression. These studies suggest that Tlx1 and Tlx3 operate high in the regulatory hierarchy that coordinates specification of dorsal horn pain-modulatory peptidergic neurons.</description><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Cholecystokinin - metabolism</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Mutation</subject><subject>Neurokinin B - metabolism</subject><subject>Neurons - metabolism</subject><subject>Neuropeptides - genetics</subject><subject>Neuropeptides - metabolism</subject><subject>Pain - metabolism</subject><subject>Pain - physiopathology</subject><subject>PAX2 Transcription Factor - metabolism</subject><subject>Somatostatin - metabolism</subject><subject>Spinal Cord - embryology</subject><subject>Spinal Cord - metabolism</subject><subject>Substance P - metabolism</subject><subject>Transcription Factor Brn-3A - genetics</subject><subject>Transcription Factor Brn-3A - metabolism</subject><subject>Transcription, Genetic</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctuEzEUQC0EomnhFyqvYDXh2uPnBgmF0haVtqLtgpXl8XgSo4kd7BlC_56JEhVYsbKle-6RrYPQKYE54bR-9_n67OHrzd3ics4IFRXIOQVQz9BsmuqKMiDP0QyohEowyY7QcSnfAUACkS_REVEMQEM9Q9_u-18E29ji6VLjRUq5DdEOHt9tvAtdcHYIKeLU4Y8pF9vji5QjvrUhVl9SO_Z2SPkR3_rNEFqfl8Hhaz_mFMsr9KKzffGvD-cJevh0dr-4qK5uzi8XH64qxzUbKg2-006Aklp1RLbSOQUd-FY2XAhPW8EbxjrNO6CcSw3cKsUb1TaWWMdFfYLe772bsVn71vk4ZNubTQ5rmx9NssH8O4lhZZbpp6FCEaLkJHhzEOT0Y_RlMOtQnO97G30ai5HAFOOU_hekIHQtxM4o9qDLqZTsu6fXEDC7fOYpn9nlMyDNLt-0ePr3X_6sHXpNwNs9sArL1TZkb8ra9v2EE7Pdbqma9IZBLevf5Cmlrw</recordid><startdate>20080409</startdate><enddate>20080409</enddate><creator>Xu, Yi</creator><creator>Lopes, Claudia</creator><creator>Qian, Ying</creator><creator>Liu, Ying</creator><creator>Cheng, Leping</creator><creator>Goulding, Martyn</creator><creator>Turner, Eric E</creator><creator>Lima, Deolinda</creator><creator>Ma, Qiufu</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080409</creationdate><title>Tlx1 and Tlx3 Coordinate Specification of Dorsal Horn Pain-Modulatory Peptidergic Neurons</title><author>Xu, Yi ; 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Aging - metabolism Animals Animals, Newborn Cholecystokinin - metabolism Embryo, Mammalian - metabolism Gene Expression Regulation Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Mice Mice, Transgenic Mutation Neurokinin B - metabolism Neurons - metabolism Neuropeptides - genetics Neuropeptides - metabolism Pain - metabolism Pain - physiopathology PAX2 Transcription Factor - metabolism Somatostatin - metabolism Spinal Cord - embryology Spinal Cord - metabolism Substance P - metabolism Transcription Factor Brn-3A - genetics Transcription Factor Brn-3A - metabolism Transcription, Genetic |
| title | Tlx1 and Tlx3 Coordinate Specification of Dorsal Horn Pain-Modulatory Peptidergic Neurons |
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