Alleviation of ischemia/reperfusion injury in ob/ob mice by inhibiting UCP-2 expression in fatty liver

AIM： To investigate the protective effect of target suppression of uncoupling protein-2 （UCP-2） on ischemia/ reperfusion （I/R） injury in fatty liver in ob/ob mice. METHODS： Plasmids suppressing UCP-2 expression were constructed, and transfected into fatty liver cells cultured in vitro and the ob/ob...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2008-01, Vol.14 (4), p.590-594
Hauptverfasser:	Wan, Chi-Dan, Wang, Chun-You, Liu, Tao, Cheng, Rui, Wang, Hong-Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Fatty Liver - pathology Fatty Liver - physiopathology Female Genetic Therapy - methods Ion Channels - genetics Mice Mice, Inbred C57BL Mice, Obese Mitochondrial Proteins - genetics Plasmids - pharmacology Rapid Communication Reperfusion Injury - physiopathology Reperfusion Injury - therapy Transfection Uncoupling Protein 2 动物模型缺血性损伤脂肪肝
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