Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation

Symptoms of T cell hyperactivation shape the course and outcome of HIV-1 infection, but the mechanism(s) underlying this chronic immune activation are not well understood. We find that the viral transactivator Tat promotes hyperactivation of T cells by blocking the nicotinamide adenine dinucleotide...

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Veröffentlicht in:	Cell host & microbe 2008-03, Vol.3 (3), p.158-167
Hauptverfasser:	Kwon, Hye-Sook, Brent, Michael M, Getachew, Ruth, Jayakumar, Prerana, Chen, Lin-Feng, Schnolzer, Martina, McBurney, Michael W, Marmorstein, Ronen, Greene, Warner C, Ott, Melanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line HIV-1 - immunology Human immunodeficiency virus 1 Humans Lymphocyte Activation - immunology Lysine - metabolism Mice Protein Binding Protein Interaction Mapping Sirtuin 1 Sirtuins - antagonists & inhibitors Sirtuins - deficiency Sirtuins - immunology T-Lymphocytes - immunology tat Gene Products, Human Immunodeficiency Virus - immunology tat Gene Products, Human Immunodeficiency Virus - metabolism Transcription Factor RelA - metabolism
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