Fexofenadine Brain Exposure and the Influence of Blood-Brain Barrier P-Glycoprotein After Fexofenadine and Terfenadine Administration

P-glycoprotein (P-gp) plays an important role in determining net brain uptake of fexofenadine. Initial in vivo experiments with 24-h subcutaneous osmotic minipump administration demonstrated that fexofenadine brain penetration was 48-fold higher in mdr1a(–/–) mice than in mdr1a(+/+) mice. In contras...

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Veröffentlicht in:	Drug metabolism and disposition 2009-03, Vol.37 (3), p.529-535
Hauptverfasser:	Zhao, Rong, Kalvass, J. Cory, Yanni, Souzan B., Bridges, Arlene S., Pollack, Gary M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Biological and medical sciences Blood-Brain Barrier Brain - drug effects Medical sciences Mice Pharmacology. Drug treatments Terfenadine - administration & dosage Terfenadine - analogs & derivatives Terfenadine - pharmacokinetics Terfenadine - pharmacology
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