Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice
During a genome-wide screen with RNA-mediated interference, we isolated CG8580 as a gene involved in the innate immune response of Drosophila melanogaster . CG8580 , which we called Akirin , encoded a protein that acted in parallel with the NF-κB transcription factor downstream of the Imd pathway an...
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| Veröffentlicht in: | Nature immunology 2008-01, Vol.9 (1), p.97-104 |
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| container_title | Nature immunology |
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| creator | Goto, Akira Matsushita, Kazufumi Gesellchen, Viola Chamy, Laure El Kuttenkeuler, David Takeuchi, Osamu Hoffmann, Jules A Akira, Shizuo Boutros, Michael Reichhart, Jean-Marc |
| description | During a genome-wide screen with RNA-mediated interference, we isolated
CG8580
as a gene involved in the innate immune response of
Drosophila melanogaster
.
CG8580
, which we called
Akirin
, encoded a protein that acted in parallel with the NF-κB transcription factor downstream of the Imd pathway and was required for defense against Gram-negative bacteria.
Akirin
is highly conserved, and the human genome contains two homologs, one of which was able to rescue the loss-of-function phenotype in drosophila cells. Akirins were strictly localized to the nucleus. Knockout of both
Akirin
homologs in mice showed that one had an essential function downstream of the Toll-like receptor, tumor necrosis factor and interleukin (IL)-1β signaling pathways leading to the production of IL-6. Thus, Akirin is a conserved nuclear factor required for innate immune responses. |
| doi_str_mv | 10.1038/ni1543 |
| format | Article |
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CG8580
as a gene involved in the innate immune response of
Drosophila melanogaster
.
CG8580
, which we called
Akirin
, encoded a protein that acted in parallel with the NF-κB transcription factor downstream of the Imd pathway and was required for defense against Gram-negative bacteria.
Akirin
is highly conserved, and the human genome contains two homologs, one of which was able to rescue the loss-of-function phenotype in drosophila cells. Akirins were strictly localized to the nucleus. Knockout of both
Akirin
homologs in mice showed that one had an essential function downstream of the Toll-like receptor, tumor necrosis factor and interleukin (IL)-1β signaling pathways leading to the production of IL-6. Thus, Akirin is a conserved nuclear factor required for innate immune responses.</description><identifier>ISSN: 1529-2908</identifier><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/ni1543</identifier><identifier>PMID: 18066067</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; DNA binding proteins ; Gene expression ; Genetic aspects ; Immune response ; Immunology ; Infectious Diseases ; Physiological aspects</subject><ispartof>Nature immunology, 2008-01, Vol.9 (1), p.97-104</ispartof><rights>Springer Nature America, Inc. 2008</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-8e61409f1b141af55bcf3d3d9989be101d97dab232b309852c5972de27ecd2973</citedby><cites>FETCH-LOGICAL-c516t-8e61409f1b141af55bcf3d3d9989be101d97dab232b309852c5972de27ecd2973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ni1543$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ni1543$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Goto, Akira</creatorcontrib><creatorcontrib>Matsushita, Kazufumi</creatorcontrib><creatorcontrib>Gesellchen, Viola</creatorcontrib><creatorcontrib>Chamy, Laure El</creatorcontrib><creatorcontrib>Kuttenkeuler, David</creatorcontrib><creatorcontrib>Takeuchi, Osamu</creatorcontrib><creatorcontrib>Hoffmann, Jules A</creatorcontrib><creatorcontrib>Akira, Shizuo</creatorcontrib><creatorcontrib>Boutros, Michael</creatorcontrib><creatorcontrib>Reichhart, Jean-Marc</creatorcontrib><title>Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice</title><title>Nature immunology</title><addtitle>Nat Immunol</addtitle><description>During a genome-wide screen with RNA-mediated interference, we isolated
CG8580
as a gene involved in the innate immune response of
Drosophila melanogaster
.
CG8580
, which we called
Akirin
, encoded a protein that acted in parallel with the NF-κB transcription factor downstream of the Imd pathway and was required for defense against Gram-negative bacteria.
Akirin
is highly conserved, and the human genome contains two homologs, one of which was able to rescue the loss-of-function phenotype in drosophila cells. Akirins were strictly localized to the nucleus. Knockout of both
Akirin
homologs in mice showed that one had an essential function downstream of the Toll-like receptor, tumor necrosis factor and interleukin (IL)-1β signaling pathways leading to the production of IL-6. Thus, Akirin is a conserved nuclear factor required for innate immune responses.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>DNA binding proteins</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Immune response</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Physiological aspects</subject><issn>1529-2908</issn><issn>1529-2916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqVks9q3DAQxkVoaf60eQZBoSUHp5Jsy9alsA1NGggNpO1ZyNLYq9QruZIdklfLQ-SZIuOysKWHFh0kNL_v04xmEDqm5JSSvP7gLC2LfA8d0JKJjAnKX2zPpN5HhzHeEkKLihev0D6tCeeEVwcorH7aYF3EKgBe227dP2DtXYRwBwa7SfegAh6CH2GmAvyabEiR1gf89Tx7evyUGRjAGXAj7sABhvshQIzWO2wdNsFHP6xtr7ByBm-shtfoZav6CG9-70fox_nn72dfsqvri8uz1VWmS8rHrAZOCyJa2tCCqrYsG93mJjdC1KIBSqgRlVENy1mTE1GXTJeiYgZYBdowUeVH6OPiO0zNBoxOGQbVyyHYjQoP0isrdyPOrmXn7yTjNSmq2eDtYtCpHqR1rU-Y3tio5YoKwmlFRJmo079QaRlI1XoHrU33WwH_X8H8wsmOIDEj3I-dmmKUl99uds3_lZ193y2sTk2KAdrt31Ai56mSy1Ql8P0CxgS4DoK89VNwqXl_ks8Dsspt</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Goto, Akira</creator><creator>Matsushita, Kazufumi</creator><creator>Gesellchen, Viola</creator><creator>Chamy, Laure El</creator><creator>Kuttenkeuler, David</creator><creator>Takeuchi, Osamu</creator><creator>Hoffmann, Jules A</creator><creator>Akira, Shizuo</creator><creator>Boutros, Michael</creator><creator>Reichhart, Jean-Marc</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>5PM</scope></search><sort><creationdate>20080101</creationdate><title>Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice</title><author>Goto, Akira ; Matsushita, Kazufumi ; Gesellchen, Viola ; Chamy, Laure El ; Kuttenkeuler, David ; Takeuchi, Osamu ; Hoffmann, Jules A ; Akira, Shizuo ; Boutros, Michael ; Reichhart, Jean-Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-8e61409f1b141af55bcf3d3d9989be101d97dab232b309852c5972de27ecd2973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>DNA binding proteins</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Immune response</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Physiological aspects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goto, Akira</creatorcontrib><creatorcontrib>Matsushita, Kazufumi</creatorcontrib><creatorcontrib>Gesellchen, Viola</creatorcontrib><creatorcontrib>Chamy, Laure El</creatorcontrib><creatorcontrib>Kuttenkeuler, David</creatorcontrib><creatorcontrib>Takeuchi, Osamu</creatorcontrib><creatorcontrib>Hoffmann, Jules A</creatorcontrib><creatorcontrib>Akira, Shizuo</creatorcontrib><creatorcontrib>Boutros, Michael</creatorcontrib><creatorcontrib>Reichhart, Jean-Marc</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goto, Akira</au><au>Matsushita, Kazufumi</au><au>Gesellchen, Viola</au><au>Chamy, Laure El</au><au>Kuttenkeuler, David</au><au>Takeuchi, Osamu</au><au>Hoffmann, Jules A</au><au>Akira, Shizuo</au><au>Boutros, Michael</au><au>Reichhart, Jean-Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><date>2008-01-01</date><risdate>2008</risdate><volume>9</volume><issue>1</issue><spage>97</spage><epage>104</epage><pages>97-104</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>During a genome-wide screen with RNA-mediated interference, we isolated
CG8580
as a gene involved in the innate immune response of
Drosophila melanogaster
.
CG8580
, which we called
Akirin
, encoded a protein that acted in parallel with the NF-κB transcription factor downstream of the Imd pathway and was required for defense against Gram-negative bacteria.
Akirin
is highly conserved, and the human genome contains two homologs, one of which was able to rescue the loss-of-function phenotype in drosophila cells. Akirins were strictly localized to the nucleus. Knockout of both
Akirin
homologs in mice showed that one had an essential function downstream of the Toll-like receptor, tumor necrosis factor and interleukin (IL)-1β signaling pathways leading to the production of IL-6. Thus, Akirin is a conserved nuclear factor required for innate immune responses.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>18066067</pmid><doi>10.1038/ni1543</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nature immunology, 2008-01, Vol.9 (1), p.97-104 |
| issn | 1529-2908 1529-2916 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2680477 |
| source | Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Biomedical and Life Sciences Biomedicine DNA binding proteins Gene expression Genetic aspects Immune response Immunology Infectious Diseases Physiological aspects |
| title | Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice |
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