Novel Escherichia coli RF1 mutants with decreased translation termination activity and increased sensitivity to the cytotoxic effect of the bacterial toxins Kid and RelE

Novel mutations in prfA, the gene for the polypeptide release factor RF1 of Escherichia coli, were isolated using a positive genetic screen based on the parD (kis, kid) toxin-antitoxin system. This original approach allowed the direct selection of mutants with altered translational termination effic...

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Veröffentlicht in:	Molecular microbiology 2009-01, Vol.71 (1), p.66-78
Hauptverfasser:	Diago-Navarro, Elizabeth, Mora, Liliana, Buckingham, Richard H, Díaz-Orejas, Ramón, Lemonnier, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Toxins - metabolism Bacteriology Biological and medical sciences Cellular biology Codon, Terminator E coli Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Genetic Complementation Test Genetics Microbiology Miscellaneous Mutagenesis Mutation Peptide Chain Termination, Translational Peptide Termination Factors - genetics Peptide Termination Factors - metabolism Peptides Toxicity Toxins
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