The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

A major mechanism in the cellular defense against oxidative or electrophilic stress is activation of the Nrf2-antioxidant response element signaling pathway, which controls the expression of genes whose protein products are involved in the detoxication and elimination of reactive oxidants and electr...

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Veröffentlicht in:	The Journal of biological chemistry 2009-05, Vol.284 (20), p.13291-13295
Hauptverfasser:	Nguyen, Truyen, Nioi, Paul, Pickett, Cecil B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Antioxidants Cell Line, Tumor Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Gene Expression Regulation - physiology Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kelch-Like ECH-Associated Protein 1 Mice Minireviews NF-E2-Related Factor 2 - biosynthesis NF-E2-Related Factor 2 - genetics Oxidative Stress - physiology Reactive Oxygen Species - metabolism Response Elements - physiology Signal Transduction - physiology Transcription, Genetic - physiology
Online-Zugang:	Volltext
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