A large-scale screen for coding variants in SERT/SLC6A4 in autism spectrum disorders

In the current study we explored the hypothesis that rare variants in SLC6A4 contribute to autism susceptibility and to rigid‐compulsive behaviors in autism. We made use of a large number of unrelated cases with autism spectrum disorders (∼350) and controls (∼420) and screened for rare exonic varian...

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Veröffentlicht in:	Autism research 2008-08, Vol.1 (4), p.251-257
Hauptverfasser:	Sakurai, Takeshi, Reichert, Jennifer, Hoffman, Ellen J., Cai, Guiqing, Jones, Hywel B., Faham, Malek, Buxbaum, Joseph D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Autistic Disorder - epidemiology Autistic Disorder - genetics Compulsive Behavior - epidemiology Compulsive Behavior - psychology Genetic Variation - genetics Humans Male Pedigree rare variants resequencing rigid-compulsive behavior serotonin Serotonin Plasma Membrane Transport Proteins - genetics Young Adult
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