Differential Allelic Expression of Dopamine D1 Receptor Gene ( DRD1 ) Is Modulated by microRNA miR-504

Background Previously, we reported that dopamine D1 receptor gene ( DRD1 ) is associated with nicotine dependence (ND) and demonstrated that two alleles (A and G) of polymorphism rs686 in the 3′-untranslated region (3′UTR) of DRD1 are expressed differentially. However, the mechanism underlying the d...

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Veröffentlicht in:	Biological psychiatry (1969) 2009-04, Vol.65 (8), p.702-705
Hauptverfasser:	Huang, Weihua, Li, Ming D
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 3′ untranslated region (3′ UTR) Addictive behaviors Adult and adolescent clinical studies Alleles Base Sequence Biological and medical sciences Cell Line dopamine D1 receptor (DRD1) Gene Expression Humans Medical sciences microRNA (miRNA) MicroRNAs - genetics MicroRNAs - metabolism MicroRNAs - pharmacology Mutagenesis, Site-Directed nicotine dependence (ND) Polymorphism, Single Nucleotide Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Dopamine D1 - genetics Receptors, Dopamine D1 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism single nucleic polymorphism (SNP) Tobacco smoking Tobacco, tobacco smoking Toxicology Transfection Up-Regulation
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