Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis

Muscle protein synthesis and mTORC1 signalling are concurrently stimulated following muscle contraction in humans. In an effort to determine whether mTORC1 signalling is essential for regulating muscle protein synthesis in humans, we treated subjects with a potent mTORC1 inhibitor (rapamycin) prior...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of physiology 2009-04, Vol.587 (7), p.1535-1546
Hauptverfasser:	Drummond, Micah J., Fry, Christopher S., Glynn, Erin L., Dreyer, Hans C., Dhanani, Shaheen, Timmerman, Kyle L., Volpi, Elena, Rasmussen, Blake B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Amino Acids - blood Exercise Humans Hydrocortisone - blood Insulin - blood Intracellular Signaling Peptides and Proteins - metabolism Male Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Muscle Contraction Muscle Proteins - biosynthesis Muscle, Skeletal - drug effects Muscle, Skeletal - enzymology Muscle, Skeletal - metabolism Peptide Elongation Factor 2 - metabolism Phosphorylation Protein Biosynthesis - drug effects Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - blood Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Ribosomal Protein S6 Kinases - metabolism Signal Transduction - drug effects Sirolimus - administration & dosage Sirolimus - blood Skeletal Muscle and Exercise Time Factors TOR Serine-Threonine Kinases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!