Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease

The purpose of this study was to use serial imaging to gain insight into the sequence of pathologic events in Alzheimer's disease, and the clinical features associated with this sequence. We measured change in amyloid deposition over time using serial 11C Pittsburgh compound B (PIB) positron em...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2009-05, Vol.132 (5), p.1355-1365
Hauptverfasser:	Jack, Clifford R., Lowe, Val J., Weigand, Stephen D., Wiste, Heather J., Senjem, Matthew L., Knopman, David S., Shiung, Maria M., Gunter, Jeffrey L., Boeve, Bradley F., Kemp, Bradley J., Weiner, Michael, Petersen, Ronald C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - diagnostic imaging Alzheimer Disease - pathology Alzheimer Disease - psychology Alzheimer's disease Amyloid beta-Peptides - analysis amyloid imaging Aniline Compounds Atrophy Biological and medical sciences Brain - diagnostic imaging Brain - pathology Carbon Radioisotopes Case-Control Studies Cognition Disorders - diagnostic imaging Cognition Disorders - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans longitudinal imaging Magnetic Resonance Imaging Male Medical sciences Middle Aged mild cognitive impairment Neurology Original Pittsburgh compound B Positron-Emission Tomography Radiopharmaceuticals Statistics, Nonparametric Thiazoles Time Factors
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