Quantitative Optical Spectroscopy: A Robust Tool for Direct Measurement of Breast Cancer Vascular Oxygenation and Total Hemoglobin Content In vivo
We propose the use of a robust, biopsy needle-based, fiber-optic tool for routine clinical quantification of tumor oxygenation at the time of diagnostic biopsy for breast cancer. The purpose of this study was to show diffuse reflectance spectroscopy as a quantitative tool to measure oxygenation leve...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2009-04, Vol.69 (7), p.2919-2926 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | QUINCY BROWN, J WILKE, Lee G GERADTS, Joseph KENNEDY, Stephanie A PALMER, Gregory M RAMANUJAM, Nirmala |
| description | We propose the use of a robust, biopsy needle-based, fiber-optic tool for routine clinical quantification of tumor oxygenation at the time of diagnostic biopsy for breast cancer. The purpose of this study was to show diffuse reflectance spectroscopy as a quantitative tool to measure oxygenation levels in the vascular compartment of breast cancers in vivo via an optical biopsy technique. Thirty-five patients undergoing surgical treatment for breast cancer were recruited for the study at Duke University Medical Center. Diffuse reflectance spectroscopy was performed on the tumors in situ before surgical resection, followed by needle-core biopsy of the optically measured tissue. Hemoglobin saturation and total hemoglobin content were quantified from 76 optical spectra-tissue biopsy pairs, consisting of 20 malignant, 23 benign, and 33 adipose tissues. Hemoglobin saturation in malignant tissues was significantly lower than nonmalignant tissues (P |
| doi_str_mv | 10.1158/0008-5472.CAN-08-3370 |
| format | Article |
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The purpose of this study was to show diffuse reflectance spectroscopy as a quantitative tool to measure oxygenation levels in the vascular compartment of breast cancers in vivo via an optical biopsy technique. Thirty-five patients undergoing surgical treatment for breast cancer were recruited for the study at Duke University Medical Center. Diffuse reflectance spectroscopy was performed on the tumors in situ before surgical resection, followed by needle-core biopsy of the optically measured tissue. Hemoglobin saturation and total hemoglobin content were quantified from 76 optical spectra-tissue biopsy pairs, consisting of 20 malignant, 23 benign, and 33 adipose tissues. Hemoglobin saturation in malignant tissues was significantly lower than nonmalignant tissues (P<0.002) and was negatively correlated with tumor size and pathologic tumor category (P<0.05). Hemoglobin saturation was positively correlated with total hemoglobin content in malignant tissues (P<0.02). HER2/neu-amplified tumors exhibited significantly higher total hemoglobin content (P<0.05) and significantly higher hemoglobin saturation (P<0.02), which is consistent with a model of increased angiogenesis and tumor perfusion promoted by HER2/neu amplification. Diffuse reflectance spectroscopy could aid in prognosis and prediction in breast cancer via quantitative assessment of tumor physiology at the time of diagnostic biopsy.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>DOI: 10.1158/0008-5472.CAN-08-3370</identifier><identifier>PMID: 19293184</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Antineoplastic agents ; Biological and medical sciences ; Breast Neoplasms - blood ; Breast Neoplasms - blood supply ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Female ; Fiber Optic Technology - methods ; Gynecology. Andrology. Obstetrics ; Hemoglobins - metabolism ; Humans ; Mammary gland diseases ; Medical sciences ; Oxygen - blood ; Oxygen - metabolism ; Pharmacology. Drug treatments ; Receptor, ErbB-2 - biosynthesis ; Spectrum Analysis ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 2009-04, Vol.69 (7), p.2919-2926</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-565dddefef190c220df605da09bbc137703445b7504eb0b4c3124483f8b8c5fa3</citedby><cites>FETCH-LOGICAL-c538t-565dddefef190c220df605da09bbc137703445b7504eb0b4c3124483f8b8c5fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21678476$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19293184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>QUINCY BROWN, J</creatorcontrib><creatorcontrib>WILKE, Lee G</creatorcontrib><creatorcontrib>GERADTS, Joseph</creatorcontrib><creatorcontrib>KENNEDY, Stephanie A</creatorcontrib><creatorcontrib>PALMER, Gregory M</creatorcontrib><creatorcontrib>RAMANUJAM, Nirmala</creatorcontrib><title>Quantitative Optical Spectroscopy: A Robust Tool for Direct Measurement of Breast Cancer Vascular Oxygenation and Total Hemoglobin Content In vivo</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>We propose the use of a robust, biopsy needle-based, fiber-optic tool for routine clinical quantification of tumor oxygenation at the time of diagnostic biopsy for breast cancer. The purpose of this study was to show diffuse reflectance spectroscopy as a quantitative tool to measure oxygenation levels in the vascular compartment of breast cancers in vivo via an optical biopsy technique. Thirty-five patients undergoing surgical treatment for breast cancer were recruited for the study at Duke University Medical Center. Diffuse reflectance spectroscopy was performed on the tumors in situ before surgical resection, followed by needle-core biopsy of the optically measured tissue. Hemoglobin saturation and total hemoglobin content were quantified from 76 optical spectra-tissue biopsy pairs, consisting of 20 malignant, 23 benign, and 33 adipose tissues. Hemoglobin saturation in malignant tissues was significantly lower than nonmalignant tissues (P<0.002) and was negatively correlated with tumor size and pathologic tumor category (P<0.05). Hemoglobin saturation was positively correlated with total hemoglobin content in malignant tissues (P<0.02). HER2/neu-amplified tumors exhibited significantly higher total hemoglobin content (P<0.05) and significantly higher hemoglobin saturation (P<0.02), which is consistent with a model of increased angiogenesis and tumor perfusion promoted by HER2/neu amplification. Diffuse reflectance spectroscopy could aid in prognosis and prediction in breast cancer via quantitative assessment of tumor physiology at the time of diagnostic biopsy.</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - blood supply</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Female</subject><subject>Fiber Optic Technology - methods</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Oxygen - blood</subject><subject>Oxygen - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptor, ErbB-2 - biosynthesis</subject><subject>Spectrum Analysis</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1u1DAUhS0EokPhEUDewC7Fv3GGBdIQflqpMAIKW8tx7MEosVPbGTGvwRPjqKMBVr6Wv3vu9TkAPMXoAmPevEQINRVngly0m09VqSkV6B5YYU6bSjDG74PViTkDj1L6Wa4cI_4QnOE1WVPcsBX4_XlWPrusstsbuJ2y02qAXyejcwxJh-nwCm7gl9DNKcObEAZoQ4RvXSwA_GhUmqMZjc8wWPgmlnuGrfLaRPhdJT0PKsLtr8PO-DIgeKh8X1RyGXFpxrAbQuc8bIPPi8SVh3u3D4_BA6uGZJ4cz3Pw7f27m_ayut5-uGo315UuX8wVr3nf98Yai9dIE4J6WyPeK7TuOo2pEIgWFzrBETMd6pimmDDWUNt0jeZW0XPw-k53mrvR9LqsENUgp-hGFQ8yKCf_f_Huh9yFvSS1EIKgIvDiKBDD7WxSlqNL2gyD8ibMSdYCo5oQVkB-B-riaYrGnoZgJJc05ZKUXJKSJU1Z6iXN0vfs3w3_dh3jK8DzI1DMVoONxXqXThzBtWiYqOkfYVyr4A</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>QUINCY BROWN, J</creator><creator>WILKE, Lee G</creator><creator>GERADTS, Joseph</creator><creator>KENNEDY, Stephanie A</creator><creator>PALMER, Gregory M</creator><creator>RAMANUJAM, Nirmala</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090401</creationdate><title>Quantitative Optical Spectroscopy: A Robust Tool for Direct Measurement of Breast Cancer Vascular Oxygenation and Total Hemoglobin Content In vivo</title><author>QUINCY BROWN, J ; WILKE, Lee G ; GERADTS, Joseph ; KENNEDY, Stephanie A ; PALMER, Gregory M ; RAMANUJAM, Nirmala</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-565dddefef190c220df605da09bbc137703445b7504eb0b4c3124483f8b8c5fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - blood supply</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Female</topic><topic>Fiber Optic Technology - methods</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Oxygen - blood</topic><topic>Oxygen - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Receptor, ErbB-2 - biosynthesis</topic><topic>Spectrum Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>QUINCY BROWN, J</creatorcontrib><creatorcontrib>WILKE, Lee G</creatorcontrib><creatorcontrib>GERADTS, Joseph</creatorcontrib><creatorcontrib>KENNEDY, Stephanie A</creatorcontrib><creatorcontrib>PALMER, Gregory M</creatorcontrib><creatorcontrib>RAMANUJAM, Nirmala</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>QUINCY BROWN, J</au><au>WILKE, Lee G</au><au>GERADTS, Joseph</au><au>KENNEDY, Stephanie A</au><au>PALMER, Gregory M</au><au>RAMANUJAM, Nirmala</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Optical Spectroscopy: A Robust Tool for Direct Measurement of Breast Cancer Vascular Oxygenation and Total Hemoglobin Content In vivo</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>69</volume><issue>7</issue><spage>2919</spage><epage>2926</epage><pages>2919-2926</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>We propose the use of a robust, biopsy needle-based, fiber-optic tool for routine clinical quantification of tumor oxygenation at the time of diagnostic biopsy for breast cancer. The purpose of this study was to show diffuse reflectance spectroscopy as a quantitative tool to measure oxygenation levels in the vascular compartment of breast cancers in vivo via an optical biopsy technique. Thirty-five patients undergoing surgical treatment for breast cancer were recruited for the study at Duke University Medical Center. Diffuse reflectance spectroscopy was performed on the tumors in situ before surgical resection, followed by needle-core biopsy of the optically measured tissue. Hemoglobin saturation and total hemoglobin content were quantified from 76 optical spectra-tissue biopsy pairs, consisting of 20 malignant, 23 benign, and 33 adipose tissues. Hemoglobin saturation in malignant tissues was significantly lower than nonmalignant tissues (P<0.002) and was negatively correlated with tumor size and pathologic tumor category (P<0.05). Hemoglobin saturation was positively correlated with total hemoglobin content in malignant tissues (P<0.02). HER2/neu-amplified tumors exhibited significantly higher total hemoglobin content (P<0.05) and significantly higher hemoglobin saturation (P<0.02), which is consistent with a model of increased angiogenesis and tumor perfusion promoted by HER2/neu amplification. Diffuse reflectance spectroscopy could aid in prognosis and prediction in breast cancer via quantitative assessment of tumor physiology at the time of diagnostic biopsy.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>19293184</pmid><doi>10.1158/0008-5472.CAN-08-3370</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antineoplastic agents Biological and medical sciences Breast Neoplasms - blood Breast Neoplasms - blood supply Breast Neoplasms - metabolism Breast Neoplasms - pathology Female Fiber Optic Technology - methods Gynecology. Andrology. Obstetrics Hemoglobins - metabolism Humans Mammary gland diseases Medical sciences Oxygen - blood Oxygen - metabolism Pharmacology. Drug treatments Receptor, ErbB-2 - biosynthesis Spectrum Analysis Tumors |
| title | Quantitative Optical Spectroscopy: A Robust Tool for Direct Measurement of Breast Cancer Vascular Oxygenation and Total Hemoglobin Content In vivo |
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