Depression, social support, and beta-adrenergic transcription control in human ovarian cancer

Abstract Motivated by previous indications that beta-adrenergic signaling can regulate tumor cell gene expression in model systems, we sought to determine whether similar dynamics occur in primary human ovarian cancer. DNA microarray analyses of 10 ovarian carcinomas identified 266 human transcripts...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2009-02, Vol.23 (2), p.176-183
Hauptverfasser:	Lutgendorf, Susan K, DeGeest, Koen, Sung, Caroline Y, Arevalo, Jesusa M, Penedo, Frank, Lucci, Joseph, Goodheart, Michael, Lubaroff, David, Farley, Donna M, Sood, Anil K, Cole, Steve W
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factors - genetics Activating Transcription Factors - metabolism Adult Aged Aged, 80 and over Allergy and Immunology Beta-adrenergic receptor Chromatography, High Pressure Liquid Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Depression - etiology Depression - genetics Depression - physiopathology Female Gene expression Gene Expression Regulation, Neoplastic Humans Middle Aged Neoplasms - metabolism NF-kappa B - genetics NF-kappa B - metabolism Norepinephrine - blood Oligonucleotide Array Sequence Analysis Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - physiopathology Ovarian Neoplasms - psychology Psychiatry Reverse Transcriptase Polymerase Chain Reaction Risk Factors Social Support Sympathetic nervous system Transcription factor Transcription, Genetic
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