SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage

Genotoxic agents such as ionizing radiation trigger cell cycle arrest at the G1/S and G2/M checkpoints, allowing cells to repair damaged DNA before entry into mitosis. DNA damage-induced G1 arrest involves p53-dependent expression of p21 (Cip1/Waf-1), which inhibits cyclin-dependent kinases and bloc...

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Veröffentlicht in:	Cellular signalling 2008-12, Vol.20 (12), p.2221-2230
Hauptverfasser:	Sitko, John C., Yeh, Brian, Kim, Moonhong, Zhou, Hong, Takaesu, Giichi, Yoshimura, Akihiko, McBride, William H., Jewett, Anahid, Jamieson, Christina A.M., Cacalano, Nicholas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell cycle Cell Cycle - radiation effects Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA Damage G1 Phase G2 Phase Mice Mice, Knockout Mitosis p21 Phosphorylation Radiation, Ionizing S Phase Signaling SOCS3 STAT1 Transcription Factor - metabolism STAT3 STAT3 Transcription Factor - metabolism Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins - metabolism Time Factors Tumor Suppressor Protein p53 - metabolism
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