Physicochemical characterization of ultrasmall superparamagnetic iron oxide particles (USPIO) for biomedical application as MRI contrast agents
Ultrasmall superparamagnetic iron oxide (USPIO) particles are maghemite or magnetite nanoparticles currently used as contrast agent in magnetic resonance imaging. The coatings surrounding the USPIO inorganic core play a major role in both the in vitro stability and, over all, USPIO's in vivo fa...
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| Veröffentlicht in: | International journal of nanomedicine 2007-01, Vol.2 (4), p.609-622 |
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| container_title | International journal of nanomedicine |
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| creator | Di Marco, Mariagrazia Sadun, Claudia Port, Marc Guilbert, Irene Couvreur, Patrick Dubernet, Catherine |
| description | Ultrasmall superparamagnetic iron oxide (USPIO) particles are maghemite or magnetite nanoparticles currently used as contrast agent in magnetic resonance imaging. The coatings surrounding the USPIO inorganic core play a major role in both the in vitro stability and, over all, USPIO's in vivo fate. Different physicochemical properties such as final size, surface charge and coating density are key factors in this respect. Up to now no precise structure--activity relationship has been described to predict entirely the USPIOs stability, as well as their pharmacokinetics and their safety. This review is focused on both the classical and the latest available techniques allowing a better insight in the magnetic core structure and the organic surface of these particles. Concurrently, this work clearly shows the difficulty to obtain a complete physicochemical characterization of USPIOs particles owing to their small dimensions, reaching the analytical resolution limits of many commercial instruments. An extended characterization is therefore necessary to improve the understanding of the properties of USPIOs when dispersed in an aqueous environment and to set the specifications and limits for their conception. |
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The coatings surrounding the USPIO inorganic core play a major role in both the in vitro stability and, over all, USPIO's in vivo fate. Different physicochemical properties such as final size, surface charge and coating density are key factors in this respect. Up to now no precise structure--activity relationship has been described to predict entirely the USPIOs stability, as well as their pharmacokinetics and their safety. This review is focused on both the classical and the latest available techniques allowing a better insight in the magnetic core structure and the organic surface of these particles. Concurrently, this work clearly shows the difficulty to obtain a complete physicochemical characterization of USPIOs particles owing to their small dimensions, reaching the analytical resolution limits of many commercial instruments. 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The coatings surrounding the USPIO inorganic core play a major role in both the in vitro stability and, over all, USPIO's in vivo fate. Different physicochemical properties such as final size, surface charge and coating density are key factors in this respect. Up to now no precise structure--activity relationship has been described to predict entirely the USPIOs stability, as well as their pharmacokinetics and their safety. This review is focused on both the classical and the latest available techniques allowing a better insight in the magnetic core structure and the organic surface of these particles. Concurrently, this work clearly shows the difficulty to obtain a complete physicochemical characterization of USPIOs particles owing to their small dimensions, reaching the analytical resolution limits of many commercial instruments. An extended characterization is therefore necessary to improve the understanding of the properties of USPIOs when dispersed in an aqueous environment and to set the specifications and limits for their conception.</description><subject>Contrast Media - chemistry</subject><subject>Dextrans</subject><subject>Ferrosoferric Oxide</subject><subject>Image Enhancement - methods</subject><subject>Iron - chemistry</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetite Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - ultrastructure</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oxides - chemistry</subject><subject>Particle Size</subject><subject>Review</subject><issn>1176-9114</issn><issn>1178-2013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpVkV1LwzAUhosobk7_ggS80YtCPto0vRFk-DGYbKi7LqdZuma0TU1acf4J_7LZnKLnJoc3L895k3MQDAlJREgxYYe7nocpIdEgOHFujXGcCJ4eBwMiKGYRFcPgc15unJZGlqrWEiokS7AgO2X1B3TaNMgUqK86C66GqkKub5VtvaWGVaM6LZG2W9O7Xirkda9UyqHLxfN8MrtChbEo16ZWyx0c2rbyzY4LDj0-TZA0zRbeIVippnOnwVEBlVNn-3MULO5uX8YP4XR2PxnfTMOWprQLCce0yDkUoohlDhJApEQRxgF4TAjNcaEiLARJckEgIty_OAWmRJqrpSgYGwXX39y2z306qbYpqqy1uga7yQzo7P9No8tsZd4yyhMu_PeOgos9wJrXXrkuW5veNj5zRn3FEcOce9f53zG__J8FsC_PhIc_</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Di Marco, Mariagrazia</creator><creator>Sadun, Claudia</creator><creator>Port, Marc</creator><creator>Guilbert, Irene</creator><creator>Couvreur, Patrick</creator><creator>Dubernet, Catherine</creator><general>Taylor & Francis Ltd</general><general>Dove Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20070101</creationdate><title>Physicochemical characterization of ultrasmall superparamagnetic iron oxide particles (USPIO) for biomedical application as MRI contrast agents</title><author>Di Marco, Mariagrazia ; 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The coatings surrounding the USPIO inorganic core play a major role in both the in vitro stability and, over all, USPIO's in vivo fate. Different physicochemical properties such as final size, surface charge and coating density are key factors in this respect. Up to now no precise structure--activity relationship has been described to predict entirely the USPIOs stability, as well as their pharmacokinetics and their safety. This review is focused on both the classical and the latest available techniques allowing a better insight in the magnetic core structure and the organic surface of these particles. Concurrently, this work clearly shows the difficulty to obtain a complete physicochemical characterization of USPIOs particles owing to their small dimensions, reaching the analytical resolution limits of many commercial instruments. An extended characterization is therefore necessary to improve the understanding of the properties of USPIOs when dispersed in an aqueous environment and to set the specifications and limits for their conception.</abstract><cop>New Zealand</cop><pub>Taylor & Francis Ltd</pub><pmid>18203428</pmid><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Taylor & Francis Open Access; MEDLINE; DOVE Medical Press Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Contrast Media - chemistry Dextrans Ferrosoferric Oxide Image Enhancement - methods Iron - chemistry Magnetic Resonance Imaging - methods Magnetite Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure NMR Nuclear magnetic resonance Oxides - chemistry Particle Size Review |
| title | Physicochemical characterization of ultrasmall superparamagnetic iron oxide particles (USPIO) for biomedical application as MRI contrast agents |
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