Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9

Disturbances in the microcirculation can lead to secondary lymphedema, a common pathological condition that, despite its frequency, still lacks a cure. Lymphedema is clinically well described, but while the genetic underpinnings that cause lymphatic malformations and primary lymphedema are being dis...

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Veröffentlicht in:	Microvascular research 2006-11, Vol.72 (3), p.161-171
Hauptverfasser:	Rutkowski, Joseph M., Moya, Monica, Johannes, Jimmy, Goldman, Jeremy, Swartz, Melody A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement Collagen - metabolism Dendritic Cells - metabolism Dendritic Cells - pathology Dermis - metabolism Dermis - pathology Disease Models, Animal Endothelial Cells - metabolism Endothelial Cells - pathology Extracellular matrix Female Hyperplasia Lipid deposition Lipid Metabolism Lymphatic function Lymphatic Vessels - metabolism Lymphatic Vessels - pathology Lymphatic Vessels - surgery Lymphedema - genetics Lymphedema - metabolism Lymphedema - pathology Lymphography Macrophages - metabolism Macrophages - pathology Matrix Metalloproteinase 9 - genetics Mice Mice, Inbred BALB C Mice, Inbred Strains Mice, Knockout MMP-9 Subcutaneous Tissue - metabolism Subcutaneous Tissue - pathology Tail - metabolism Tail - pathology Tail - surgery Time Factors Vascular Endothelial Growth Factor C - metabolism VEGF-C
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